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Titolo:
The effects of granulocyte colony stimulating factor on chemiluminescence and lipid peroxidation of blood platelets treated with cisplatin
Autore:
Olas, B; Wachowicz, B; Buczynski, A;
Indirizzi:
Univ Lodz, Inst Biochem, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz Poland PL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Mil Sch Med, Dept Prevent Med, PL-90647 Lodz, Poland Mil Sch Med Lodz Poland PL-90647 Dept Prevent Med, PL-90647 Lodz, Poland
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 2, volume: 11, anno: 2000,
pagine: 79 - 84
SICI:
0959-4973(200002)11:2<79:TEOGCS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTORS; IN-VITRO; CHEMOTHERAPY; CELLS; ACTIVATION; CANCER; SENSITIVITY; MECHANISMS; CARCINOMA; CYTOKINES;
Keywords:
blood platelets; chemiluminescence; cisplatin; granulocyte colony stimulating factor; lipid peroxidation; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Olas, B Univ Lodz, Inst Biochem, Dept Gen Biochem, Banacha 12-16, PL-90237Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 L-90237 Lodz, Poland
Citazione:
B. Olas et al., "The effects of granulocyte colony stimulating factor on chemiluminescence and lipid peroxidation of blood platelets treated with cisplatin", ANTI-CANC D, 11(2), 2000, pp. 79-84

Abstract

The effects of granulocyte colony stimulation factor (G-CSF) at concentrations of 0.08, 0.8 and 8 mu g/ml on reactive oxygen species (ROS) generationand lipid peroxidation induced by cisplatin in pig blood platelets were investigated. The revel of reactive oxygen species (O-2(.-), H2O2, singlet oxygen and organic radicals) generated in platelets was measured by the chemiluminescence method. Lipid peroxidation was determined by the thiobarbituric acid technique and was expressed as thiobarbituric acid reactive substances. G-CSF at the concentration of 0.08 mu g/ml had a strong inhibitory effect (about 60% inhibition) on the production of ROS in the isolated pig platelets. This cytokine also significantly reduced lipid peroxidation in control platelets and platelets treated with cisplatin (p < 0.05). In the presence of G-CSF in the incubation medium (0.8 mu g/ml) cisplatin-induced generation of nos was also reduced (p < 0.05). This study demonstrates that G-CSFhas a protective effect against the oxidative stress in blood platelets caused by cisplatin. [(C) 2000 Lippincott Williams & Wilkins.].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:57:11