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Titolo:
Adenosine, AMP, and protein phosphatase activity in sandfly saliva
Autore:
Katz, O; Waitumbi, JN; Zer, R; Warburg, A;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Kuvin Ctr Study Infect & Trop Dis, Dept Parasitol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 1, volume: 62, anno: 2000,
pagine: 145 - 150
SICI:
0002-9637(200001)62:1<145:AAAPPA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLY LUTZOMYIA-LONGIPALPIS; NITRIC-OXIDE PRODUCTION; LEISHMANIA-MAJOR; PHLEBOTOMUS-PAPATASI; RAW-264.7 MACROPHAGES; VASODILATORY PEPTIDE; VECTOR SALIVA; INFECTION; MICE; PSYCHODIDAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, O Hebrew Univ Jerusalem, Hadassah Med Sch, Kuvin Ctr Study Infect & Trop Dis, Dept Parasitol, POB 12272, IL-91120 Jerusalem, Israel Hebrew UnivJerusalem POB 12272 Jerusalem Israel IL-91120 Israel
Citazione:
O. Katz et al., "Adenosine, AMP, and protein phosphatase activity in sandfly saliva", AM J TROP M, 62(1), 2000, pp. 145-150

Abstract

As they probe the skin for blood, sand flies inject saliva that prevents hemostasis. Sand fly saliva also promotes leishmaniasis by suppressing immunologic functions of macrophages. Saliva of Phlebotomus papatasi, the vectorof Old World cutaneous leishmaniasis, contains adenosine and AMP. We show that Ph. papatasi saliva as well as pure adenosine down-regulate the expression of the inducible nitric oxide (NO) synthase gene in activated macrophages. In addition Ph. papatasi, but not Lutzomyia longipalpis, saliva inhibits the production of NO. Taken together, these data suggest that salivary adenosine is responsible for the down-regulation of NO synthesis. Saliva of both genera Phlebotomus and Lutzomyia contains significant levels of endogenous protein phosphatase-1/2A-like activity that is heat labile, inhibitable by okadaic acid and calyculine a, and does not require divalent cations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:48:22