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Titolo:
Proton magnetic resonance spectroscopy of the medial prefrontal cortex in patients with deficit schizophrenia: Preliminary report
Autore:
Delamillieure, P; Fernandez, J; Constans, JM; Brazo, P; Benali, K; Abadie, P; Vasse, T; Thibaut, F; Coutheoux, P; Petit, M; Dollfus, S;
Indirizzi:
CHU Caen, Grp Imagerie Neurofonct, CNRS FRE 2233, CEA,LRC 13V,Ctr Esquirol, F-14000 Caen, France CHU Caen Caen France F-14000 ,LRC 13V,Ctr Esquirol, F-14000 Caen, France CHU Caen, Dept Imagerie Resonance Magnet, F-14000 Caen, France CHU Caen Caen France F-14000 erie Resonance Magnet, F-14000 Caen, France Ctr Cyceron, Caen, France Ctr Cyceron Caen FranceCtr Cyceron, Caen, France
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 4, volume: 157, anno: 2000,
pagine: 641 - 643
SICI:
0002-953X(200004)157:4<641:PMRSOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL LOBES; ABNORMALITIES; PATHOLOGY; SCHEDULE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Dollfus, S CHU Caen, Grp Imagerie Neurofonct, CNRS FRE 2233, CEA,LRC 13V,Ctr Esquirol, F-14000 Caen, France CHU Caen Caen France F-14000 r Esquirol, F-14000 Caen, France
Citazione:
P. Delamillieure et al., "Proton magnetic resonance spectroscopy of the medial prefrontal cortex in patients with deficit schizophrenia: Preliminary report", AM J PSYCHI, 157(4), 2000, pp. 641-643

Abstract

Objective: Proton magnetic resonance spectroscopy (H-1-MRS) was used to study medial prefrontal metabolic impairments in schizophrenic patients with the deficit syndrome. Method: The subjects were 22 schizophrenic patients categorized as deficit (N=5) or non-deficit (N=17) and 21 healthy subjects. H-1-MRS was performed for the right and the left medial prefrontal cortex. Results: The patients with the deficit syndrome had significantly lower ratios of N-acetylaspartate to creatine plus phosphocreatine than did the healthy subjects or nondeficit patients. Conclusions: As N-acetylaspartate levels could reflect neuronal density and/or viability, this finding suggests aneuronal loss in the medial prefrontal cortex of deficit patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:49:56