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Titolo:
High levels of dopamine activity in the basal ganglia of cigarette smokers
Autore:
Salokangas, RKR; Vilkman, H; Ilonen, T; Taiminen, T; Bergman, J; Haaparanta, M; Solin, O; Alanen, A; Syvalahti, E; Hietala, J;
Indirizzi:
Univ Turku, Cent Hosp, Dept Psychiat, FIN-20520 Turku, Finland Univ TurkuTurku Finland FIN-20520 pt Psychiat, FIN-20520 Turku, Finland Univ Turku, Cent Hosp, Dept Diagnost Radiol, FIN-20520 Turku, Finland UnivTurku Turku Finland FIN-20520 nost Radiol, FIN-20520 Turku, Finland Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland Univ Turku Turku Finland ept Pharmacol & Clin Pharmacol, Turku, Finland Turku PET Ctr, Accelerator Lab, Turku, Finland Turku PET Ctr Turku Finland ku PET Ctr, Accelerator Lab, Turku, Finland
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 4, volume: 157, anno: 2000,
pagine: 632 - 634
SICI:
0002-953X(200004)157:4<632:HLODAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOKING; BRAIN; INHIBITION; NICOTINE; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Salokangas, RKR Univ Turku, Cent Hosp, Dept Psychiat, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 -20520 Turku, Finland
Citazione:
R.K.R. Salokangas et al., "High levels of dopamine activity in the basal ganglia of cigarette smokers", AM J PSYCHI, 157(4), 2000, pp. 632-634

Abstract

Objective: The authors' goal was to study presynaptic dopamine activity insmoking and nonsmoking human subjects in vivo. Method: [F-18]Fluorodopa ([F-18]DOPA) uptake K-i values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography Results: Significantly higher [F-18]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Conclusions: Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activitymay be a relevant mechanism in dependence on cigarette smoking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:00:09