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Titolo:
Association analysis of 5HT transporter gene in bipolar disorder in the Indian population
Autore:
Saleem, Q; Ganesh, S; Vijaykumar, M; Reddy, YCJ; Brahmachari, SK; Jain, S;
Indirizzi:
Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India Indian Inst Sci Bangalore Karnataka India 560012 560012, Karnataka, India Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India Ctr Biochem Technol, Funct Gen Unit, Delhi, India Ctr Biochem Technol Delhi India m Technol, Funct Gen Unit, Delhi, India
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 2, volume: 96, anno: 2000,
pagine: 170 - 172
SICI:
0148-7299(20000403)96:2<170:AAO5TG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER; 5-HTT GENE; SUSCEPTIBILITY; POLYMORPHISM; DEPRESSION; ILLNESS;
Keywords:
bipolar disorder; serotonin transporter gene (SERT); VNTR polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Jain, S 29,Type 4,Block 5,NIMHANS Campus, Bangalore 560011, Karnataka, India 29,Type 4,Block 5,NIMHANS Campus Bangalore Karnataka India 560011
Citazione:
Q. Saleem et al., "Association analysis of 5HT transporter gene in bipolar disorder in the Indian population", AM J MED G, 96(2), 2000, pp. 170-172

Abstract

A variable number tandem repeat (VNTR) polymorphism consisting of multiplecopies of a 17-bp repeat in the second intron of the serotonin transportergene (SERT) has been reported. Different alleles of this VNTR have been found to be associated with bipolar disorder and schizophrenia. These findings have been confirmed in some populations, but disconfirmed in others. Furthermore, significant ethnic variations in the distribution of these allelesboth in normal and patient populations also have been reported. We analyzed the VNTR polymorphism in 50 Indian patients with bipolar disorder and in ethnically matched controls. Two alleles corresponding to 10 and 12 repeatsof the VNTR were found in both groups. There were no significant differences either in allele frequency or genotype frequency between the two groups. The nine-repeat allele that has been reported in Japanese and Caucasian populations was absent in our sample, Although it will be important to extendthe present study in a larger sample, our initial results do not suggest any large association with alleles of the VNTR in the SERT gene and bipolar disorder in Indian patients. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:10:48