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Titolo:
Familial association between allergic disorders and depression in adult Finnish twins
Autore:
Wamboldt, MZ; Hewitt, JK; Schmitz, S; Wamboldt, FS; Rasanen, M; Koskenvuo, M; Romanov, K; Varjonen, J; Kaprio, J;
Indirizzi:
Natl Jewish Med & Res Ctr, Denver, CO 80206 USA Natl Jewish Med & Res CtrDenver CO USA 80206 s Ctr, Denver, CO 80206 USA Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado, Inst Behav Genet, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Inst Behav Genet, Denver, CO 80262 USA Univ Helsinki, Dept Publ Hlth, Helsinki, Finland Univ Helsinki Helsinki Finland sinki, Dept Publ Hlth, Helsinki, Finland Univ Helsinki, Dept Med, Div Pulm Med, Helsinki, Finland Univ Helsinki Helsinki Finland ept Med, Div Pulm Med, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Psychiat, Helsinki, Finland Univ Helsinki Helsinki Finland t Hosp, Dept Psychiat, Helsinki, Finland Turku Univ, Dept Publ Hlth, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Publ Hlth, Turku, Finland Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland h & Alcohol Res, Helsinki, Finland
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 2, volume: 96, anno: 2000,
pagine: 146 - 153
SICI:
0148-7299(20000403)96:2<146:FABADA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT DISORDER; EXPRESSED EMOTION; PANIC DISORDER; SPECTRUM DISORDERS; CHILD INTERACTION; BRONCHIAL-ASTHMA; ATOPIC DISORDERS; SYMPTOMS; POPULATION; GENETICS;
Keywords:
genetics; atopy; depression; twin study; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Wamboldt, MZ Natl Jewish Med & Res Ctr, 140 Jackson St,Room K701, Denver, CO 80206 USA Natl Jewish Med & Res Ctr 140 Jackson St,Room K701 Denver CO USA 80206
Citazione:
M.Z. Wamboldt et al., "Familial association between allergic disorders and depression in adult Finnish twins", AM J MED G, 96(2), 2000, pp. 146-153

Abstract

Clinical studies have shown a relationship between allergic disorders and depression, panic disorder, attention deficit/hyperactivity disorder, and social anxiety for a significant subset of patients with these disorders. The nature of the relationship, whether due to shared environmental or biologic vulnerabilities or as a result of the stress of chronic illness, has been less clear. By examining the covariance of atopic disorders and depressive symptoms in a community sample of monozygotic (MZ) and dizygotic (DZ) twins, the contribution of genetic and/or shared environmental etiological factors can be established. A Finnish sample of 1337 MZ and 2506 DZ twin pairs, ages 33-60 years, was sent questionnaires inquiring about history of asthma, eczema, and atopic rhinitis, as well as the Beck Depression Inventory (BDI), The nature of the covariation between twins of these symptoms was investigated by fitting competing genetic and environmental models. Within-person correlation between atopic symptoms and BDI was 0.103 (P < 0.001) for the total sample. Using the Mx statistical modeling program to fit the data to competing quantitative genetic models, the best fitting model estimated that 64%, of the association between atopy and BDI was due to shared familial vulnerability, primarily additive genetic influences. Although the measures for allergic disorders and depression are crude, this study supports the hypothesis that there is a small shared genetic risk for atopic and depressive symptoms, and if replicated, may open research for common mechanisms between allergic and depressive disorders. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 25/01/20 alle ore 18:45:17