Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Novel polymorphisms of the human cholecystokinin A receptor gene: An association analysis with schizophrenia
Autore:
Tachikawa, H; Harada, S; Kawanishi, Y; Okubo, T; Shiraishi, H;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3050003, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3050003 sukuba, Ibaraki 3050003, Japan Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3050003, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3050003 sukuba, Ibaraki 3050003, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 2, volume: 96, anno: 2000,
pagine: 141 - 145
SICI:
0148-7299(20000403)96:2<141:NPOTHC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMAL LOCALIZATION; BIPOLAR DISORDER; A RECEPTOR; DOPAMINE; EXPRESSION; PROMOTER; RELEASE; OBESITY; 4P;
Keywords:
schizophrenia; polymorphism; association analysis; CCK-AR gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tachikawa, H Univ Tsukuba, Inst Clin Med, Dept Psychiat, 2-21-14 Sakura, Tsukuba, Ibaraki 3050003, Japan Univ Tsukuba 2-21-14 Sakura Tsukuba Ibaraki Japan 3050003 pan
Citazione:
H. Tachikawa et al., "Novel polymorphisms of the human cholecystokinin A receptor gene: An association analysis with schizophrenia", AM J MED G, 96(2), 2000, pp. 141-145

Abstract

The cholecystokinin A receptor (CCK-AR) modulates CCK-stimulated dopamine release in the posterior nucleus accumbens, and its gene is mapped to 4p15.2-15.1 with the dopamine receptor 5 (DR5) gene. We speculated that alterations in the CCK-AR lead to an increase in dopamine release, which may in turn constitute a predisposition in schizophrenia. We investigated genetic variations in the promoter region and the coding region of the CCK-AR gene, Anassociation analysis was conducted between 83 unrelated schizophrenic patients and 80 healthy controls. Novel polymorphisms (201A-->G, 246G-->A in the promoter region, 1260T-->A, 1266T-->C in intron 1 within the 3' mRNA splice acceptor site consensus sequence, and Leu3OBLeu in exon 5) were found inaddition to the variants (608G-->A in intron 1, 3849C-->T [Ile296Ile] in exon 5) reported previously. Significant differences were found in the allele frequencies of the 201A-->G nucleotide substitution in the promoter region between patients and controls (P = 0.0181, odds ratio: 1.972, after Bonferroni correction: P = 0.0543), These differences were also found between the patients with paranoid type and controls (P = 0.0274, odds ratio = 3.667,after Bonferroni correction: P = 0.0822), Our analyses suggest that the 201A allele frequency was higher in the schizophrenic group, especially in the paranoid type, than in the control group at a rate that was not quite significant after Bonferroni correction. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:24:53