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Titolo:
Angiogenesis in cutaneous lymphoproliferative disorders - Microvessel density discriminates between cutaneous B-cell lymphomas and B-cell pseudolymphomas
Autore:
Schaerer, L; Schmid, MH; Mueller, B; Dummer, RG; Burg, G; Kempf, W;
Indirizzi:
Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF DERMATOPATHOLOGY
fascicolo: 2, volume: 22, anno: 2000,
pagine: 140 - 143
SICI:
0193-1091(200004)22:2<140:AICLD->2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TUMOR; CLASSIFICATION; INHIBITION;
Keywords:
cutaneous B-cell lymphoma; B-cell pseudolymphomas; angiogenesis; microvessel density; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kempf, W Univ Zurich Hosp, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland Univ Zurich Hosp Gloriastr 31 Zurich Switzerland CH-8091 zerland
Citazione:
L. Schaerer et al., "Angiogenesis in cutaneous lymphoproliferative disorders - Microvessel density discriminates between cutaneous B-cell lymphomas and B-cell pseudolymphomas", AM J DERMAT, 22(2), 2000, pp. 140-143

Abstract

The role of angiogenesis in neoplastic disorders is supported by the evidence that tumor growth beyond a certain size requires induction of new bloodvessels. The extent of tumor-associated angiogenesis, measured as microvessel density (MVD), has shown to correlate with aggressiveness and the prognostic outcome in several malignant neoplasms. Few data have been reported on the angiogenic response in lymphoproliferative diseases. In this study, the MVD has been assessed in benign and malignant primary cutaneous B-cell lymphoproliferative disorders. MVD was determined in formaldehyde-fixed, paraffin-embedded specimens of primary cutaneous B-cell lymphomas (CBCL n = 18) and cutaneous B-cell pseudolymphomas (B-PSL; n = 22) according to previously described protocols but was performed using computer-aided microscopic morphometry. The endothelial cells of microvessels were identified by immunohistochemical staining for factor VIII-related antigen and CD31. The MVD was 99 dots/mm(2) for CBCL and 68 dots/mm(2) for PSL, and a MVD of 115 dots/mm(2) for CBCL and 73 dots/mm(2) for PSL by using an antibody against factor VIII-related antigen and CD31 antigen, respectively. Univariate analysis revealed statistically highly significant differences in MVD between CBCL and B-PSL (P = 0.0036 with staining for factor Vm-related antigen and P = 0.0002 with staining for CD31 antigen). This study analyzes for the first time the angiogenic response in CBCL compared with that of B-PSL and demonstrates that MVD discriminates between CBCL and B-PSL. However, because of an overlap in the ranges of MVD in CBCL and PSL, the MVD is not useful as a diagnostic tool in individual cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:11:40