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Titolo:
MK-801 blocks the development of behavioral sensitization to ethanol
Autore:
Camarini, R; Frussa, R; Monteiro, MG; Calil, HM;
Indirizzi:
Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil Univ Fed Sao PauloSao Paulo Brazil Dept Psychobiol, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil Univ Fed Sao Paulo Sao Paulo Brazil , Dept Pharmacol, Sao Paulo, Brazil
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 3, volume: 24, anno: 2000,
pagine: 285 - 290
SICI:
0145-6008(200003)24:3<285:MBTDOB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; EXCITATORY AMINO-ACIDS; VENTRAL TEGMENTAL AREA; D-ASPARTATE RECEPTORS; COCAINE SENSITIZATION; LOCOMOTOR-ACTIVITY; INBRED MICE; RAT-BRAIN; AMPHETAMINE; ABUSE;
Keywords:
ethanol; sensitization; MK-801; N-methyl-D-aspartate; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Camarini, R Univ Calif San Francisco, Dept Neurol, Gallo Ctr, 5858 Horton St,Suite 200, Emeryville, CA 94608 USA Univ Calif San Francisco 5858 HortonSt,Suite 200 Emeryville CA USA 94608
Citazione:
R. Camarini et al., "MK-801 blocks the development of behavioral sensitization to ethanol", ALC CLIN EX, 24(3), 2000, pp. 285-290

Abstract

Background: Studies have indicated that MK-801 (a noncompetitive N-methyl-D-aspartate receptor antagonist) participates in the long-term neural changes responsible for sensitization to stimulant drugs. It is known that repeated administration of low doses of ethanol sensitizes animals to its stimulant effect. In this work we investigated whether MK-801 alters the development of behavioral sensitization to ethanol. Methods: Groups of male Swiss mice were treated with saline or ethanol (2.0 g/kg) plus saline or MK-801 (0.25 mg/kg) for 21 days. On day 25, all animals received an ethanol challenge injection (2.0 g/kg). We measured locomotor activity on days 1, 7, 14, 21 and 25. In addition, we assessed the effects of different doses of MK-801 on the response to a low dose of ethanol (2.0 g/kg). Results: Ethanol-treated mice developed sensitization to the locomotor-stimulating effect of the drug, whereas those concomitantly receiving ethanol and MK-801 did nut. All doses of MK-801 that were used stimulated the locomotor activity of both ethanol and saline-treated animals. Conclusions: The findings support the hypothesis that N-methyl-D-aspartatereceptors have an important role in the development of sensitization to drugs of abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:50:52