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Titolo:
Effect of carbon dioxide on cochlear blood flow in guinea pigs
Autore:
Ugnell, AO; Hasegawa, M; Lundquist, PG; Andersson, R;
Indirizzi:
Linkoping Univ, Dept Biomed Engn, Linkoping, Sweden Linkoping Univ Linkoping Sweden iv, Dept Biomed Engn, Linkoping, Sweden Kyorin Univ, Dept Otorhinolaryngol Head & Neck Surg, Tokyo, Japan Kyorin Univ Tokyo Japan Otorhinolaryngol Head & Neck Surg, Tokyo, Japan Linkoping Univ, Dept Med & Care, Div Otorhinolaryngol Head & Neck Surg, Linkoping, Sweden Linkoping Univ Linkoping Sweden gol Head & Neck Surg, Linkoping, Sweden Linkoping Univ, Dept Med & Care, Div Pharmacol, Linkoping, Sweden Linkoping Univ Linkoping Sweden Care, Div Pharmacol, Linkoping, Sweden
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 1, volume: 120, anno: 2000,
pagine: 11 - 18
SICI:
0001-6489(2000)120:1<11:EOCDOC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER FLOWMETRY; CO2; DIAMETER; ARTERIES; TENSION; PH;
Keywords:
dose dependence; laser Doppler flowmetry; pH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ugnell, AO Linkoping Univ Hosp, Dept Hlth & Care, Div Anesthesiol & IntensCare, SE-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden SE-58185 nkoping, Sweden
Citazione:
A.O. Ugnell et al., "Effect of carbon dioxide on cochlear blood flow in guinea pigs", ACT OTO-LAR, 120(1), 2000, pp. 11-18

Abstract

The influence of carbon dioxide (CO2) on cochlear blood flow (CBF), blood pressure (SBP) and skin blood how (SBF) was studied in anaesthetized guineapigs. A transient acute respiratory acidosis was produced by inhalation ofCO2 and oxygen (O-2) gas mixtures. The blood flows were measured by laser Doppler flowmetry (LDF). High CO2 increased CBF and SEP, and decreased SBF in a dose-dependent manner. The responses of CBF, SEP and SBF to high CO2 were reversible. Our results indicate that high CO2 (and low pH) dilates thesmooth muscle of the blood vessels, resulting in an increase in CBF. CO2 also activates the sympathetic nervous system in the whole body, producing an increase in SEP. The distribution of alpha-adrenergic fibres/receptors isabundant in skin and scarce in the cochlea. The constrictive effect on blood vessels is much greater in the skin than in the cochlea, thus our results showed a decrease in SBF during stimulation with higher CO2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:29:17