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Titolo:
Genetic patterning of embryonic inner ear development
Autore:
Represa, J; Frenz, DA; Van de Water, TR;
Indirizzi:
Albert Einstein Coll Med, Kennedy Ctr, Dept Otolaryngol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 laryngol, Bronx, NY 10461 USA Univ Valladolid, Inst Biol & Mol Genet, Valladolid, Spain Univ ValladolidValladolid Spain st Biol & Mol Genet, Valladolid, Spain Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Neurosci, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 uct Biol, Bronx, NY 10461 USA
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 1, volume: 120, anno: 2000,
pagine: 5 - 10
SICI:
0001-6489(2000)120:1<5:GPOEIE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OTIC CAPSULE CHONDROGENESIS; TISSUE INTERACTIONS; SENSORY ORGANS; GROWTH-FACTOR; DEFECTS; ORIGIN;
Keywords:
growth factors; homeobox genes; null mutations; otic morphogenesis; otocyst; pars inferior; pars superior; transcription factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Represa, J Albert Einstein Coll Med, Kennedy Ctr, Dept Otolaryngol, Room 302,1410 Pelham Pkwy S Bronx, Bronx, NY 10461 USA Albert Einstein Coll Med Room 302,1410 Pelham Pkwy S Bronx Bronx NY USA 10461
Citazione:
J. Represa et al., "Genetic patterning of embryonic inner ear development", ACT OTO-LAR, 120(1), 2000, pp. 5-10

Abstract

The commitment of the otocyst to form balance (pars superior) and hearing (pars inferior) receptors is under the control of patterning genes. Intersecting patterns of gene expression has been proposed to explain the regionalization of inner ear sensory receptor development. Insights into the roles of patterning genes is being acquired from the analysis of inner ear development of null mutation mice. An example of the consequences of the loss of expression of a single patterning gene is the effect of a null mutation of paired-box gene 2 (Pax2) on formation of the cochlea. Pax2 transcripts are expressed in the pars inferior of the otocyst and null mutant inner ears show agenesis of the cochlea. This is an example of the profound effect that loss of a single patterning gene can have on inner ear development. However, more typically there is redundancy of gene action during inner ear development as exemplified by the overlapping pattern of expression of two closely related homeobox-containing genes (i.e. Hmx2 and Hmx3) in the pars superior of the otocyst. Hmx2 and Hmx3 genes are both expressed early in otic development with Hmx3 transcripts present in the placode. However, null mutation of the Hmx3 patterning gene produced only a limited vestibular defect, and did not result in the agenesis of the vestibule. This result suggests that then is redundancy in genes that have similar patterns of regional expression in the otic anlagen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 23:49:19