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Titolo:
Analysis of cardiac energy metabolism in valve disease using P-31-MR-spectroscopy
Autore:
Beer, M; Viehrig, M; Seyfarth, T; Sandstede, J; Lipke, C; Pabst, T; Kenn, W; Harre, K; Horn, M; Landschutz, W; von Kienlin, M; Neubauer, S; Hahn, D;
Indirizzi:
Univ Wurzburg, Inst Rontgendiagnost, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 agnost, D-97070 Wurzburg, Germany Univ Wurzburg, Phys Inst 5, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 Inst 5, D-97070 Wurzburg, Germany Univ Wurzburg, Med Klin, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 d Klin, D-97070 Wurzburg, Germany
Titolo Testata:
RADIOLOGE
fascicolo: 2, volume: 40, anno: 2000,
pagine: 162 - 167
SICI:
0033-832X(200002)40:2<162:AOCEMI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
GER
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; CREATINE-KINASE SYSTEM; HUMAN MYOCARDIUM; DILATED CARDIOMYOPATHY; PHOSPHATE-METABOLISM; PRESSURE-OVERLOAD; NMR-SPECTROSCOPY; MR SPECTROSCOPY;
Keywords:
valve disease; valve replacement; MR-imaging; P-31-MR-spectroscopy; energy metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Beer, M Univ Wurzburg, Inst Rontgendiagnost, Josef Schneider Str 2, D-97070 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97070 many
Citazione:
M. Beer et al., "Analysis of cardiac energy metabolism in valve disease using P-31-MR-spectroscopy", RADIOLOGE, 40(2), 2000, pp. 162-167

Abstract

Purpose: Heart valve disease combined with left ventricular hypertrophy leads to derangements in cardiac energy metabolism, which can be detected non-invasively by P-31-MR-spectroscopy. The purpose of the present study was to examine whether the derangements in cardiac metabolism are reversible after surgical valve replacement. Patients and methods: 10 healthy volunteers and 10 patients with aortic stenosis (pressure gradients >60 mmHg) were included. For assessment of energy metabolism,P-31-MR spectra were obtained with a double oblique 3D-CSI technique (voxel size 25 cm(3)). In 5 of 10 patients,follow-up examination wasperformed 3 months after surgical valve replacement (SVR). Left ventricular (LV) function was analyzed by cine MRI. Results: Before SVR the myocardial phosphocreatine to adenosinetriphosphate (PCr-ATP) ratio was significantly (p=0.0002) reduced to 0.80+/-0.25 in patients compared to 1.65+/-0.21 in volunteers. 3 months after SVR, LV mass had significantly (p=0.04) decreased from 238+/-33 g to 206+/-47 g. At the same time a significant (p=0.04) increase of the PCr-ATP ratio from 0.80+/-0.25 to 1.28+/-0.22 was observed. A slight, but not significant, reduction of the phosphodiester ATP ratio was observed before SVR, with a trend towards normalization after SVR. Conclusions: After SVR, the deranged energy metabolism shows a trend towards normalization. Further follow-up is necessary to determine whether complete normalization of the energetic derangement can be observed over longer periods of time following SVR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:15:57