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Titolo:
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Autore:
Herrero, JF; Laird, JMA; Lopez-Garcia, JA;
Indirizzi:
Univ Alcala de Henares, Dept Fisiol, Madrid 28871, Spain Univ Alcala de Henares Madrid Spain 28871 pt Fisiol, Madrid 28871, Spain
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 2, volume: 61, anno: 2000,
pagine: 169 - 203
SICI:
0301-0082(200006)61:2<169:WOSCNA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; NMDA-RECEPTOR ANTAGONIST; SUBSTANTIA GELATINOSA NEURONS; SPINOTHALAMIC TRACT NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; INDUCED SECONDARY HYPERALGESIA; PRIMARY AFFERENT-FIBERS; LONG-TERM POTENTIATION; C-FIBER; IN-VITRO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
201
Recensione:
Indirizzi per estratti:
Indirizzo: Herrero, JF Univ Alcala de Henares, Dept Fisiol, Edificio Med,Campus Univ,Madrid 28871, Spain Univ Alcala de Henares Edificio Med,Campus Univ Madrid Spain 28871
Citazione:
J.F. Herrero et al., "Wind-up of spinal cord neurones and pain sensation: much ado about something?", PROG NEUROB, 61(2), 2000, pp. 169-203

Abstract

Wind-up is a frequency-dependent increase in the excitability of spinal cord neurones, evoked by electrical stimulation of afferent C-fibres. Although it has been studied over the past thirty years, there are still uncertainties about its physiological meaning. Glutamate (NMDA) and tachykinin NK1 receptors are required to generate wind-up and therefore a positive modulation between these two receptor types has been suggested by some authors. However, most drugs capable of reducing the excitability of spinal cord neurones, including opioids and NSAIDs, can also reduce or even abolish wind-up. Thus, other theories involving synaptic efficacy, potassium channels, calcium channels, etc, have also been proposed for the generation of this phenomenon. Whatever the mechanisms involved in its generation, wind-up has been interpreted as a system for the amplification in the spinal cord of the nociceptive message that arrives from peripheral nociceptors connected to C-fibres. This probably reflects the physiological system activated in the spinal cord after an intense or persistent barrage of afferent nociceptive impulses. On the other hand, wind-up, central sensitisation and hyperalgesia are not the same phenomena, although they may share common properties. Wind-up can be an important tool to study the processing of nociceptive information in the spinal cord, and the central effects of drugs that modulate the nociceptive system. This paper reviews the physiological and pharmacologicaldata on wind-up of spinal cord neurones, and the perceptual correlates of wind-up in human subjects, in the context of its possible relation to the triggering of hyperalgesic stales, and also the multiple factors which contribute to the generation of wind-up. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:53:21