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Titolo:
Copper(II) complexes of deltakephalin and its analogues containing alpha-hydroxymethylserine
Autore:
Kowalik-Jankowska, T; Lesniak, W; Brasun, J; Stasiak, M; Leplawy, MT;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Lodz Tech Univ, Inst Organ Chem, PL-90924 Lodz, Poland Lodz Tech Univ Lodz Poland PL-90924 st Organ Chem, PL-90924 Lodz, Poland
Titolo Testata:
POLYHEDRON
fascicolo: 2, volume: 19, anno: 2000,
pagine: 241 - 245
SICI:
0277-5387(20000130)19:2<241:CCODAI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING ABILITY; AMINO-ACIDS; PEPTIDE; IONS; CU(II);
Keywords:
copper(II) complexes; deltakephalins; stability constants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kowalik-Jankowska, T Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw F Joliot Curie 14 Wroclaw Poland PL-50383
Citazione:
T. Kowalik-Jankowska et al., "Copper(II) complexes of deltakephalin and its analogues containing alpha-hydroxymethylserine", POLYHEDRON, 19(2), 2000, pp. 241-245

Abstract

Potentiometric and spectroscopic data have shown that deltakephalin and its derivatives containing the alpha-hydroxymethylserine (HmS) residue in thesecond and in the second and sixth positions form the same series of complexes: CuHL, CuL, CuH-1L, CuH-2L and CuH-3L (1N to 4N binding mode). The alcoholic groups in the amino acid side chain are very effective in the stabilization of the complexes formed (the protonation corrected stability constants, log K*, values of 4N complexes are - 22.55 and - 21.15 for deltakephalin and its derivative containing the HmS residue in the second and sixth positions, respectively). There is no evidence for the direct involvement of alcoholic groups of HmS in binding of CU2+ ions and there is no indication of binding through the tyrosine-phenolate oxygen atoms, either. (C) 2000 Elsevier Science Ltd All rights reserved.

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Documento generato il 29/11/20 alle ore 18:29:23