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Titolo:
Development of specific connectivity between premotor neurons and motoneurons in the brain stem and spinal cord
Autore:
Glover, JC;
Indirizzi:
Univ Oslo, Dept Anat, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317Univ Oslo, Dept Anat, N-0317 Oslo, Norway
Titolo Testata:
PHYSIOLOGICAL REVIEWS
fascicolo: 2, volume: 80, anno: 2000,
pagine: 615 - 647
SICI:
0031-9333(200004)80:2<615:DOSCBP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GROWTH-CONE GUIDANCE; EMBRYONIC CHICK HINDLIMB; FLOOR PLATE DIFFERENTIATION; INITIAL TRACT FORMATION; MUSCLE SENSORY NEURONS; MUSCULATURE FOLLOWING TRANSPLANTATION; SYMPATHETIC PREGANGLIONIC NEURONS; MICE LACKING NEUROTROPHIN-3; BONE MORPHOGENETIC PROTEINS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
346
Recensione:
Indirizzi per estratti:
Indirizzo: Glover, JC Univ Oslo, Dept Anat, PB 1105 Blindern, N-0317 Oslo, Norway Univ Oslo PB 1105 Blindern Oslo Norway N-0317 317 Oslo, Norway
Citazione:
J.C. Glover, "Development of specific connectivity between premotor neurons and motoneurons in the brain stem and spinal cord", PHYSIOL REV, 80(2), 2000, pp. 615-647

Abstract

Development of Specific Connectivity Between Premotor Neurons and Motoneurons in the Brain Stem and Spinal Cord. Physiol. Rev. 80: 615-647, 2000. -Astounding progress has been made during the past decade in understanding thegeneral principles governing the development of the nervous system. An area of prime physiological interest that is being elucidated is how the neural circuitry that governs movement is established. The concerted applicationof molecular biological, anatomical, an electrophysiological techniques tothis problem is yielding gratifying insight into how motoneuron, interneuron,:and sensory neuron identities are determined, how these different neuron types establish specific axonal projections,and;how they recognize and synapse upon each other in patterns that enable the nervous system to exercise precise control over skeletal musculature. This review is an;attempt to convey to the physiologist some of the exciting:discoveries that have been made, within a context that is intended to link molecular mechanism to behavioral realization. The focus is restricted to the development of monosynaptic connections onto skeletal motoneurons. Principal topics include the inductive mechanisms that pattern the placement and differentiation of motoneurons,:Ia sensory afferents, and premotor interneurons; the molecular guidance mechanisms that pattern the projection of premotor axons in the brain stem and spinal cord; and the precision with which initial synaptic connections onto motoneurons are established, with emphasis on the relative roles played by cellular recognition versus electrical:activity. Id is hoped that this review will provide a guide to understanding both the existing literature and the advances that await this rapidly developing topic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:03:34