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Titolo:
ATP-binding cassette transporter A1 (ABCA1) in macrophages: A dual function in inflammation and lipid metabolism?
Autore:
Schmitz, G; Kaminski, WE; Porsch-Ozcurumez, M; Klucken, J; Orso, E; Bodzioch, M; Buchler, C; Drobnik, W;
Indirizzi:
Univ Regensburg, Inst Klin Chem & Blutbank, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany
Titolo Testata:
PATHOBIOLOGY
fascicolo: 5-6, volume: 67, anno: 1999,
pagine: 236 - 240
SICI:
1015-2008(1999)67:5-6<236:ACTA(I>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Keywords:
ABC transporter; ABCA1; macrophage; HDL; lipid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ Regensburg, Inst Klin Chem & Blutbank, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11Regensburg Germany D-93042
Citazione:
G. Schmitz et al., "ATP-binding cassette transporter A1 (ABCA1) in macrophages: A dual function in inflammation and lipid metabolism?", PATHOBIOLOG, 67(5-6), 1999, pp. 236-240

Abstract

Activated lipid-laden macrophages in the vascular wall are key modulators of the inflammatory processes underlying atherosclerosis. We demonstrate here that the ATP-binding cassette (ABC) transporter ABCA1 is induced during differentiation of human monocytes into macrophages. ABCA1 has been implicated in macrophage interleukin-lp secretion and apoptosis. Moreover, ABCA1 mRNA and protein levels are strongly upregulated by uptake of modified LDL and downregulated by HDL3-mediated lipid efflux in macrophages. Mutation analysis in patients with the classical Tangier disease (TD), a monogenetic disorder characterized by hypersplenism, macrophage accumulation and deposition of cholesteryl esters in the reticuloendothelial system, low plasma HDL and premature atherosclerosis, revealed deleterious mutations in their ABCA1 gene. The localization pattern of the mutations within the ABCA1 protein appears to determine the tropism for either the reticuloendothelial system,as seen in the classical TD phenotype, or the artery wall, as in the case of HDL deficiency in the absence of splenomegaly. In a comprehensive analysis of the expression and regulation of all currently known human ABC transporters, we identified additional cholesterol-responsive genes that are induced during monocyte differentiation into macrophages, Our results indicate a dual regulatory function for ABCA1 in macrophage lipid metabolism and inflammation. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:17:42