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Titolo:
A new resorbable implant for bone and cartilage defect repair. Results of an experimental animal study
Autore:
Jansson, V; Muller, PE; Thal, S; Arnholz, C; Milz, S; Koch, KU; Refior, HJ;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Orthopad Klin & Poliklin, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 n & Poliklin, D-81377 Munich, Germany
Titolo Testata:
ORTHOPADE
fascicolo: 2, volume: 29, anno: 2000,
pagine: 151 - 157
SICI:
0085-4530(200002)29:2<151:ANRIFB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL ADAPTATION; TISSUE; POLYMERS; CHAMBER; RABBITS; GRAFTS;
Keywords:
bioimplant; biomechanics; cartilage defect; cartilage repair; mesenchymal cell differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Jansson, V Univ Munich, Klinikum Grosshadern, Orthopad Klin & Poliklin, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
V. Jansson et al., "A new resorbable implant for bone and cartilage defect repair. Results of an experimental animal study", ORTHOPADE, 29(2), 2000, pp. 151-157

Abstract

Hyaline cartilage is thought to be unable to regenerate. All efforts so far - including autologous chondrocyte cell transplantation to reconstruct cartilage defects in joints have not been totally convincing. However, mesenchymal cells are able to differentiate into chondrocytes under mechanical pressure conditions. In this study, an open porous resorbable two-layer "bioimplant" was constructed in which mechanical pressure was exerted onto mesenchymal cells when migrated into the open porous structure of the bioimplant. Differentiation of the cells into chondrocytes was thus induced. The bioimplants were implanted into the medial condyles of nine rabbits and left inplace for eight or twelve weeks, respectively. In seven of these cases, cartilage formation was found, in contrary to the controls in which only connective tissue and bone had grown into the empty holes. The new bioimplants have proven their effectiveness in cartilage defect repair and might evolvein the future as a new alternative treatment of full thickness defects of joint surfaces.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 20:01:20