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Titolo:
Nutrition and neurodevelopment: mechanisms of developmental dysfunction and disease in later life
Autore:
Dauncey, MJ; Bicknell, RJ;
Indirizzi:
Babraham Inst, Dev Genet Programme, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT amme, Cambridge CB2 4AT, England Babraham Inst, Neurobiol Programme, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT amme, Cambridge CB2 4AT, England
Titolo Testata:
NUTRITION RESEARCH REVIEWS
fascicolo: 2, volume: 12, anno: 1999,
pagine: 231 - 253
SICI:
0954-4224(199912)12:2<231:NANMOD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRENATAL PROTEIN-MALNUTRITION; LONG-TERM POTENTIATION; FATTY-ACID COMPOSITION; KINDLING-INDUCED ALTERATIONS; OPTIMAL MENTAL-DEVELOPMENT; GRANULE CELL EXCITABILITY; MESSENGER-RNA EXPRESSION; DEVELOPING RAT-BRAIN; EARLY POSTNATAL LIFE; LOW-BIRTH-WEIGHT;
Keywords:
neurodevelopment; fetal nutrition; infant nutrition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
146
Recensione:
Indirizzi per estratti:
Indirizzo: Bicknell, RJ Babraham Inst, Dev Genet Programme, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT ge CB2 4AT, England
Citazione:
M.J. Dauncey e R.J. Bicknell, "Nutrition and neurodevelopment: mechanisms of developmental dysfunction and disease in later life", NUTR RES R, 12(2), 1999, pp. 231-253

Abstract

Nutrition plays a central role in linking the fields of developmental neurobiology and cognitive neuroscience. It has a profound impact on the development of brain structure and function and malnutrition can result in developmental dysfunction and disease in later life. A number of diseases, including schizophrenia, may be related to neurodevelopmental insults such as malnutrition, hypoxia, viruses or in utero drug exposure. Some of the most significant findings on nutrition and neurodevelopment during the last three decades, and especially during the last few years, are discussed in this review. Attention is focused on the underlying cellular and molecular mechanisms by which diet exerts its effects. Randomized intervention studies have revealed important effects of early nutrition on later cognitive development, and recent epidemiological findings show that both genetics and environment are risk factors for schizophrenia. Particularly important is the effectof early nutrition on developmentof the hippocampus, a brain structure important in establishing learning and memory, and hence for cognitive performance. A major aim of future research should be to elucidate the molecular mechanisms underlying nutritionally-induced impairment of neurodevelopment and specifically to determine the mechanisms by which early nutritional experience affects later cognitive performance. Key research objectives should include: (1) increased understanding of mechanisms underlying the normal processes of ageing and neurodegenerative disorders; (2) assessment of the role of susceptibility genes in modulating the effects of early nutrition on neurodevelopment; and (3) development of nutritional and pharmaceutical strategies for preventing and/or ameliorating the adverse effects of early malnutrition on long-term programming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:36:39