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Titolo:
Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)
Autore:
Abrahams, S; Leigh, PN; Harvey, A; Vythelingum, GN; Grise, D; Goldstein, LH;
Indirizzi:
Univ London Kings Coll, Inst Psychiat, Dept Psychol, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF l, London SE5 8AF, England Guys Kings & St Thomas Sch Med, Inst Psychiat, Dept Clin Neurosci, London,England Guys Kings & St Thomas Sch Med London England Neurosci, London,England
Titolo Testata:
NEUROPSYCHOLOGIA
fascicolo: 6, volume: 38, anno: 2000,
pagine: 734 - 747
SICI:
0028-3932(2000)38:6<734:VFAEDI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURON DISEASE; POSITRON EMISSION TOMOGRAPHY; COMPUTED-TOMOGRAPHY; NEUROPSYCHOLOGICAL DEFICITS; FRONTOTEMPORAL DEMENTIA; COGNITIVE IMPAIRMENT; LOBE; INTELLIGENCE; PET; MEMORY;
Keywords:
motor neurone disease; cognition; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Abrahams, S Univ London Kings Coll, Inst Psychiat, Dept Psychol, De Crespigny Pk, London SE5 8AF, England Univ London Kings Coll De Crespigny Pk London England SE5 8AF
Citazione:
S. Abrahams et al., "Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)", NEUROPSYCHO, 38(6), 2000, pp. 734-747

Abstract

Neuropsychological investigations of amyotrophic lateral sclerosis (ALS) patients have revealed variable results on specific tests, despite a similaroverall cognitive profile of predominantly executive dysfunction with someevidence of memory impairment. The most striking and consistent deficit isfound using tests of verbal fluency. The current investigation explored why verbal fluency is particularly sensitive to the impairment in ALS, by investigating some of the underlying cognitive processes: (i) intrinsic response generation; (ii) phonological loop functions; and (iii) simple work retrieval. Twenty-two ALS patients and 25 healthy controls were investigated. The battery included: (i) written and spc,ken letter-based fluency, categoryfluency, design fluency, (ii) the Phonological Similarities effect and Word Length Effect; and (iii) computerised sentence completion and confrontational naming. The tests were designed to control for motor speed and to accommodate for the range of disabilities that are present in ALS patients. Significant impairments were found on some tests of intrinsic response generation, namely the Written Verbal Fluency Test, Category Fluency Test (generation of animal names) and Design Fluency Test. Phonological loop functions appeared to be intact with evidence of both the Phonological Similarities and Word Length Effects, but the ALS patients displayed significantly reducedworking memory capacity. No deficits were found on tests of simple word retrieval. The findings indicate that verbal fluency impairments in ALS patients result from a higher order dysfunction, implicating deficits in the supervisory attentional system or central executive component of working memory, and are not caused or exaggerated by an impairment in phonological loop functions or in primary linguistic abilities. The study also demonstrates the importance of controlling for differences in motor speed, which may haveserved to exaggerate the presence of cognitive deficits in ALS patients reported by some other studies. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 28/11/20 alle ore 03:09:47