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Titolo:
Species differences in peroxisome proliferation; mechanisms and relevance
Autore:
Choudhury, AI; Chahal, S; Bell, AR; Tomlinson, SR; Roberts, RA; Salter, AM; Bell, DR;
Indirizzi:
Univ Nottingham, Sch Biol Sci, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Astra Charnwood Safety Assessment, Loughborough LE11 5RH, Leics, England Astra Charnwood Safety Assessment Loughborough Leics England LE11 5RH and Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ e, England
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 2, volume: 448, anno: 2000,
pagine: 201 - 212
SICI:
1386-1964(20000317)448:2<201:SDIPPM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RECEPTOR-ALPHA; ACYL-COA OXIDASE; DI(2-ETHYLHEXYL) PHTHALATE DEHP; REPLICATIVE DNA-SYNTHESIS; ACID OMEGA-HYDROXYLASE; APOLIPOPROTEIN C-III; COENZYME-A OXIDASE; GUINEA-PIG; PPAR-ALPHA; LAURIC-ACID;
Keywords:
peroxisome proliferation-activated receptor alpha (PPAR alpha); pleiotropic response; peroxisome proliferators;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Bell, DR Univ Nottingham, Sch Biol Sci, Univ Pk, Nottingham NG7 2RD, England Univ Nottingham Univ Pk Nottingham England NG7 2RD 2RD, England
Citazione:
A.I. Choudhury et al., "Species differences in peroxisome proliferation; mechanisms and relevance", MUT RES-F M, 448(2), 2000, pp. 201-212

Abstract

Peroxisome proliferators are a class of structurally diverse chemicals, which induce liver carcinogenesis in rodents through interaction and activation of the Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha). PPAR alpha agonists elicit a powerful pleiotropic response, which include hypolipidaemia. We have examined the response of species that are classically unresponsive to peroxisome proliferators. Whereas hamster responds to PPAR alpha agonists by hepatomegaly and induction of marker genes, the guinea pig does not undergo hepatomegaly or induction of marker genes, such as CYP4A13. Both the hamster and the guinea pig have PPAR alpha, and the guinea pigreceptor has been characterised to be fully functional. as demonstrated inreporter gene expression assays. However, the guinea pig PPAR alpha is expressed at low levels in liver, and the currently favoured hypothesis to explain species differences in hepatic peroxisome proliferation invokes the low level of PPAR alpha as the principal determinant of species responsiveness. However, the demonstration that guinea pigs and humans undergo hypolipidaemia induced by PPAR alpha-agonists calls into question the mode of actionof PPAR alpha agonists in "non-responsive" species. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:23:30