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Titolo:
Value of nedocromil-natrium in the treatment of childhood and adolescent asthma
Autore:
Konig, P;
Indirizzi:
Univ Missouri, Dept Child Hlth, Columbia, MO 65201 USA Univ Missouri Columbia MO USA 65201 pt Child Hlth, Columbia, MO 65201 USA
Titolo Testata:
MONATSSCHRIFT KINDERHEILKUNDE
fascicolo: 2, volume: 148, anno: 2000,
pagine: 106 - 112
SICI:
0026-9298(200002)148:2<106:VONITT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
EXERCISE-INDUCED ASTHMA; SODIUM CROMOGLYCATE; INDUCED BRONCHOCONSTRICTION; BECLOMETHASONE DIPROPIONATE; CROMOLYN SODIUM; DOUBLE-BLIND; BRONCHIAL HYPERRESPONSIVENESS; HISTAMINE-SECRETION; CLINICAL EFFICACY; MAST-CELLS;
Keywords:
nedocromil sodium, cromolyn sodium; childhood asthma; anti-inflammatory; non-steroidal anti-inflammatory drugs; dosing frequency; steroid-sparing effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Konig, P Childrens Hosp, Sch Med, Hlth Sci Ctr N708, 1 Hosp Dr, Columbia, MO 65212 USA Childrens Hosp 1 Hosp Dr Columbia MO USA 65212 mbia, MO 65212 USA
Citazione:
P. Konig, "Value of nedocromil-natrium in the treatment of childhood and adolescent asthma", MONATS KIND, 148(2), 2000, pp. 106-112

Abstract

Nedocromil sodium and cromolyn sodium are non-steroidal, anti-inflammatorydrugs for the treatment of asthma. Although they are chemically different,there are many similarities in their mechanism of action. In provocation tests they have equal efficacy on some tests (allergen, exercise), but nedocromil sodium has greater effect on neuronal mechanisms such as So(2) challenge. Very few studies compared the two drugs. In children, only one study was done, showing that twice daily nedocromil is as effective as four times daily cromolyn sodium. Thus twice daily administration is one advantage of nedocromil, the other being proven effect of steroid-sparing, which has not been shown with cromolyn sodium. Both drugs are recommended as first-line agents in mild persistent asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:48:23