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Titolo:
MODIFICATION OF ODD-CHAIN LENGTH UNSATURATED FATTY-ACIDS BY HEPATOCYTES OF RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) FED DIETS CONTAINING FISH-OIL OR OLIVE OIL
Autore:
RODRIGUEZ C; HENDERSON RJ; PORTER AEA; DICK JR;
Indirizzi:
UNIV LA LAGUNA,FAC BIOL,DPTO BIOL ANIM UDI FISIOL LA LAGUNA 38271 SPAIN UNIV STIRLING,DEPT BIOL & MOL SCI,NERC,UNIT AQUAT BIOCHEM STIRLING FK9 4LA SCOTLAND
Titolo Testata:
Lipids
fascicolo: 6, volume: 32, anno: 1997,
pagine: 611 - 619
SICI:
0024-4201(1997)32:6<611:MOOLUF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXISOMAL BETA-OXIDATION; RAT-LIVER; SKIN FIBROBLASTS; METABOLISM; LONG; DESATURATION; CULTURE; CELLS; RETROCONVERSION; PHOSPHOLIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Rodriguez et al., "MODIFICATION OF ODD-CHAIN LENGTH UNSATURATED FATTY-ACIDS BY HEPATOCYTES OF RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) FED DIETS CONTAINING FISH-OIL OR OLIVE OIL", Lipids, 32(6), 1997, pp. 611-619

Abstract

Hepatocytes isolated from rainbow trout fed on diets containing either fish oil or olive oil were incubated with individual odd-chain length unsaturated fatty acids (19:1n-9, 19,2n-6, 19:3n-3, 21:2n-6, 21:3n-6, 21:4n-6, 21:3n-3, and 21:5n-3) to examine whether these fatty acids were substrates for modification by desaturation and elongation. All odd-chain length fatty acids were readily assimilated into the lipids of hepatocytes from both dietary groups of fish, but their conversion to longer-chain, more unsaturated derivatives was more pronounced with cells from trout fed olive oil. Thus, the conversion of 19:2n-6 and 21:2n-6 to 21:3n-6 and 21:4n-6, and of 19:3n-3 to 21:4n-3 and 21:5n-3, was most obvious in cells from the olive oil group, as was the conversion of 21:3n-6 and 21:3n-3 to 21:4n-6 and 21:4n-3, respectively. Elongation of 19:1n-9 to 21:1n-9 and 23:1n-9 occurred in cells from both groups. No 23:6n-3 was detectable as a product of 19:3n-3 or 21:3n-3. However, this fatty acid was a major product formed by cells from fish fed olive oil presented with 21:5n-3, Cells from both groups of fish incorporated 21:4n-6 and 21:5n-3 into their lipids largely without modification but chain-shortened around 40, 23, and 19% of the incorporated 21:2n-6, 21:3n-3, and 19:1n-9, respectively. The results demonstrate that odd-chain length unsaturated fatty acids can act as substrates forthe desaturation, elongation, and chain-shortening systems of trout hepatocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:31:24