Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector T cells needed to cause disease
Autore:
Sevilla, N; Homann, D; von Herrath, M; Rodriguez, F; Harkins, S; Whitton, JL; Oldstone, MBA;
Indirizzi:
Scripps Clin & Res Inst, Dept Neuropharmacol, Div Virol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 rol, La Jolla, CA 92037 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 7, volume: 74, anno: 2000,
pagine: 3284 - 3292
SICI:
0022-538X(200004)74:7<3284:VDIATM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ESCAPE VIRAL VARIANTS; BETA-CELLS; MOLECULAR CHARACTERIZATION; GLUTAMATE-DECARBOXYLASE; DNA IMMUNIZATION; IMMUNE-RESPONSE; CTL EPITOPE; IN-VIVO; MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Oldstone, MBA Scripps Clin & Res Inst, Dept Neuropharmacol, Div Virol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
N. Sevilla et al., "Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector T cells needed to cause disease", J VIROLOGY, 74(7), 2000, pp. 3284-3292

Abstract

Virus-specific cytotoxic T lymphocytes (CTL) at frequencies of >1/1,000 are sufficient to cause insulin-dependent diabetes mellitus (IDDM) in transgenic mice whose pancreatic beta cells express as "self'" antigen a protein from a virus later used to initiate infection. The inability to generate sufficient effector CTL for other cross-reacting viruses that fail to cause IDDM could be mapped to point mutations in the CTL epitope or its COO- flanking region. These data indicate that IDDM and likely other autoimmune diseases are caused by a quantifiable number of T cells, that neither standard epidemiologic markers nor molecular analysis with nucleic acid probes reliably distinguishes between viruses that do or do not cause; diabetes, and thata single-amino-acid change flanking a CTL epitope can interfere with antigen presentation and development of autoimmune disease in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:23:55