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Titolo:
A statistical-mechanical model for regulation of long-range chromatin structure and gene expression
Autore:
Ishii, H;
Indirizzi:
Brandeis Univ, Grad Program Biophys & Struct Biol, Waltham, MA 02454 USA Brandeis Univ Waltham MA USA 02454 s & Struct Biol, Waltham, MA 02454 USA
Titolo Testata:
JOURNAL OF THEORETICAL BIOLOGY
fascicolo: 3, volume: 203, anno: 2000,
pagine: 215 - 228
SICI:
0022-5193(20000407)203:3<215:ASMFRO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; MATRIX ATTACHMENT REGIONS; BETA-GLOBIN LOCUS; COOPERATIVE BINDING; TRANSCRIPTIONAL ACTIVATORS; HISTONE ACETYLATION; DROSOPHILA EMBRYO; DNA-REPLICATION; GLOBULAR DOMAIN; REPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Ishii, H Brandeis Univ, Grad Program Biophys & Struct Biol, MS 008,415 South St, Waltham, MA 02454 USA Brandeis Univ MS 008,415 South St Waltham MA USA 02454 02454 USA
Citazione:
H. Ishii, "A statistical-mechanical model for regulation of long-range chromatin structure and gene expression", J THEOR BIO, 203(3), 2000, pp. 215-228

Abstract

In eukaryotic organisms, organization of chromatin is considered to play arole in transcriptional regulation by limiting the accessibility of a geneto the transcription machinery. It is not fully understood, however, how chromatin around a particular locus can be specifically altered to allow transcription. This paper introduces a statistical-mechanical model of chromatin to illustrate a potential mechanism. The model, which is mathematically equivalent to the one-dimensional Ising model of magnetic systems, explainshow gene regulatory DNA sequences can affect the chromatin structure over a long distance in cis. The main assumption of the model is cooperativity of histone H1 in binding to the nucleosome array. This cooperativity resultsin a long-range correlation of histone H1 distribution along the chromatin. Due to this long-range correlation, a gene regulatory element, such as a transcriptional enhancer, may lead to depletion of histone H1 over a large region of chromatin thereby increasing the accessibility of the gene. The model provides a mechanism for a sensitive genetic switch and explains several aspects of gene regulation and chromatin structure. (C) 2000 Academic Press.

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Documento generato il 15/01/21 alle ore 23:20:32