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Titolo:
Helper T-cell epitope immunodominance associated with structurally stable segments of hen egg lysozyme and HIV gp120
Autore:
Landry, SJ;
Indirizzi:
Tulane Univ, Sch Med, Dept Biochem, New Orleans, LA 70112 USA Tulane UnivNew Orleans LA USA 70112 t Biochem, New Orleans, LA 70112 USA
Titolo Testata:
JOURNAL OF THEORETICAL BIOLOGY
fascicolo: 3, volume: 203, anno: 2000,
pagine: 189 -
SICI:
0022-5193(20000407)203:3<189:HTEIAW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II MOLECULES; LIMITED PROTEOLYTIC SITES; HLA-DR; INVARIANT CHAIN; CATHEPSIN-B; ENVELOPE GLYCOPROTEIN; PROTEIN INHIBITORS; HYDROGEN-EXCHANGE; CRYSTAL-STRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Landry, SJ Tulane Univ, Sch Med, Dept Biochem, 1430 Tulane Ave, New Orleans, LA 70112USA Tulane Univ 1430 Tulane Ave New Orleans LA USA 70112 A 70112USA
Citazione:
S.J. Landry, "Helper T-cell epitope immunodominance associated with structurally stable segments of hen egg lysozyme and HIV gp120", J THEOR BIO, 203(3), 2000, pp. 189

Abstract

Although many antigen sequences potentially can bind to the MHCII proteins, only a small number of epitopes dominate the immune response. Additional mechanisms of processing, presentation or recognition must restrict the immune response against a large portion of the antigen. A highly significant correlation is found between epitope immunodominance and local structural stability in hen egg lysozyme. Since antigen proteins are likely to retain substantial native-like structure in the processing compartment, protease action may be focused on regions that are most readily accommodated in the protease active sites, and thus, the intervening sequence are preferentially presented. Immunodominance also correlates with sequence conservation as expected from the constraints imposed by structure. These results suggest thatthe three-dimensional structure of the antigen limits the immune response against some antigen segments. For HIV gp120, a substantial improvement in the accuracy of epitope prediction is obtained by combining rules for MHCIIbinding with a restriction of the predicted epitopes to well-conserved sequences. (C) 2000 Academic Press.

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Documento generato il 08/07/20 alle ore 07:46:56