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Titolo:
Time window for clinical effectiveness of mass evacuation in a rat balloonmodel mimicking an intraparenchymatous hematoma
Autore:
Valdes, EL; Lain, AH; Calandre, L; Grau, M; Cabello, A; Gomez-Escalonilla, C;
Indirizzi:
12 Octubre Univ Hosp, Dept Neurol, Madrid, Spain 12 Octubre Univ Hosp Madrid Spain Univ Hosp, Dept Neurol, Madrid, Spain 12 Octubre Univ Hosp, Dept Pathol, Madrid, Spain 12 Octubre Univ Hosp Madrid Spain Univ Hosp, Dept Pathol, Madrid, Spain 12 Octubre Univ Hosp, Res Ctr, Madrid, Spain 12 Octubre Univ Hosp MadridSpain bre Univ Hosp, Res Ctr, Madrid, Spain
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 174, anno: 2000,
pagine: 40 - 46
SICI:
0022-510X(20000301)174:1<40:TWFCEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; PROSPECTIVE RANDOMIZED TRIAL; BRAIN-BARRIER PERMEABILITY; CEREBRAL BLOOD-FLOW; HEMODYNAMIC-CHANGES; PROGNOSTIC FACTORS; EDEMA FORMATION; LESION; COMPRESSION; MECHANISMS;
Keywords:
intracerebral hematoma; rats; surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Calandre, L 12 Octubre Univ Hosp, Dept Neurol, Madrid, Spain 12 Octubre Univ Hosp Madrid Spain ept Neurol, Madrid, Spain
Citazione:
E.L. Valdes et al., "Time window for clinical effectiveness of mass evacuation in a rat balloonmodel mimicking an intraparenchymatous hematoma", J NEUR SCI, 174(1), 2000, pp. 40-46

Abstract

The purpose of this study is to evaluate in a rat model if the early removal of an experimental intracerebral mass mimicking an extensive subcorticalhematoma improves neurological outcome. Fifty six male Wistar rats were studied. A balloon was placed sterotactically at the level of the striatum. The balloon was inflated to 100 mu l for periods of 10, 60 or 130 min (with 10 animals in each group). In Ib animals the balloon was not deflated and there were four sham operated cases. Neurological deficit was evaluated by ablinded observer by means of a clinical scale from 0 to 8 points at 24 and72 h after inflation. Three additional animals at each inflation period were sacrificed after 6 h for pathological study with hematoxylin-eosin staining. Death rate was 9/10 animals who had permanent inflation. 4/10 in thosewith 2 h inflation, 2/10 for 1 h inflation and 0/10 for 10 min inflation (P<0.01 in chi square test). Many animals developed a particular clinical syndrome not previously described. Mean 72 h clinical scores (0-8 points) were: 7.6 (S.D.: 1.2) for the permanent inflation group, 4.4 (S.D.: 3.2) for 2h of inflation, 2.3 (S.D.: 3.2) for 1 h and 0.4 (0.9) for 10 min of inflation (P<0.01 in Kruskal Wallis test). In the pathological study the rate of damaged neurons was significantly higher in the permanent than in transientinflation groups. In conclusion, in this balloon model evacuation of an extensive acute expanding subcortical (hematoma-like) mass must be performed within a limited time window to prevent the development of irreversible neurological deficits or death. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:06:31