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Titolo:
Locally activated renin-angiotensin system associated with TGF-beta 1 as amajor factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats
Autore:
Kashiwagi, M; Shinozaki, M; Hirakata, H; Tamaki, K; Hirano, T; Tokumoto, M; Goto, H; Okuda, S; Fujishima, M;
Indirizzi:
Kyushu Univ, Fac Med, Dept Internal Med 2, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 2, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 4, volume: 11, anno: 2000,
pagine: 616 - 624
SICI:
1046-6673(200004)11:4<616:LARSAW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; EXPERIMENTAL GLOMERULONEPHRITIS; EXTRACELLULAR-MATRIX; GLOMERULAR DAMAGE; CONVERTING ENZYME; MESANGIAL CELLS; HYPERTENSION; EXPRESSION; FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kashiwagi, M Kyushu Univ, Fac Med, Dept Internal Med 2, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 8128582 8582, Japan
Citazione:
M. Kashiwagi et al., "Locally activated renin-angiotensin system associated with TGF-beta 1 as amajor factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats", J AM S NEPH, 11(4), 2000, pp. 616-624

Abstract

Chronic inhibition of nitric oxide synthase (NOS) is known to cause renal parenchymal injury with systemic hypertension. To elucidate the pathogenetic mechanism in renal damage induced by NOS inhibition, N-omega-nitro-L-arginine methyl ester (L-NAME) was given orally for 12 wk in Wistar rats, and the roles of tissue renin-angiotensin system and transforming growth factor-beta 1 (TGF-beta 1) were investigated. BP and urinary protein excretion increased significantly in L-NAME rats compared with control rats, and glomerulosclerosis and interstitial fibrosis developed. In L-NAME rats, the cortical tissue levels of angiotensin-converting enzyme activity and angiotensin II were significantly higher than those in control rats. The cortical mRNA expressions of both TGF-beta 1 and fibronectin were significantly elevated in L-NAME rats. Immunohistochemically, increased expressions of both fibronectin and alpha-smooth muscle actin were also revealed in L-NAME rats. In L-NAME rats, these histologic injuries and the increased expression of TGF-beta 1 were equally ameliorated by either angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist, but not by hydralazine. In conclusion, the locally activated renin-angiotensin system in connection with the increased TGF-beta 1 expression is a major pathogenetic feature of renal injury in chronically NOS-inhibited rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:13:25