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Titolo:
PULMONARY ALVEOLAR MICROLITHIASIS - A CLINICOPATHOLOGICAL AND CHEMICAL-ANALYSIS OF 7 CASES
Autore:
MORAN CA; HOCHHOLZER L; HASLETON PS; JOHNSON FB; KOSS MN;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL WASHINGTON DC20306 ARMED FORCES INST PATHOL,DEPT CHEM PATHOL WASHINGTON DC 20306 UNIV S MANCHESTER HOSP,WYTHENSHAWE HOSP,DEPT PATHOL MANCHESTER M20 8LR LANCS ENGLAND
Titolo Testata:
Archives of pathology and laboratory medicine
fascicolo: 6, volume: 121, anno: 1997,
pagine: 607 - 611
SICI:
0003-9985(1997)121:6<607:PAM-AC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSSIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Moran et al., "PULMONARY ALVEOLAR MICROLITHIASIS - A CLINICOPATHOLOGICAL AND CHEMICAL-ANALYSIS OF 7 CASES", Archives of pathology and laboratory medicine, 121(6), 1997, pp. 607-611

Abstract

Objectives,To determine the clinical features and outcome of patientswith pulmonary alveolar microlithiasis and to determine the chemical composition of the microliths. Case Material.-We studied seven cases of pulmonary alveolar microlithiasis. The patients were six women and one man, aged 19 to 70 years (mean age 44.5 years). Clinically, five patients were known to have suffered from this condition for 5 to 41 years. One patient presented with shortness of breath, and another had a gradual decrease in exercise tolerance. None of the patients had a previous history of disturbances in metabolism or any other relevant medical condition. Reports on radiographic studies were available in six cases, and chest radiographs were available for review in the seventh case. They all showed diffuse bilateral pulmonary infiltrates. Open lung biopsies were performed in two patients, and autopsy lung material was reviewed in five patients. Results.-Histologically, the lung showedthe typical features of pulmonary alveolar microlithiasis, that is, presence of numerous microliths filling the alveolar spaces with eithera normal or thickened fibrotic interstitium. Chemical analysis performed on the lung tissue of six of these patients revealed that the microliths consisted principally of calcium and phosphorus salts. Five of these patients died of respiratory failure; however, their deaths occurred from 5 to 41 years following the initial diagnosis. No follow-up information was obtained in two patients. Conclusions.-The findings ofthis study confirm that pulmonary alveolar microlithiasis can be seenin any age group and that the microliths are composed principally of salts of calcium and phosphorus. Additionally, these cases confirm that the disease typically follows a protracted course.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:28:08