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Titolo:
Antidepressant-like activity of amisulpride in two animal models of depression
Autore:
Papp, M; Wieronska, J;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 14, anno: 2000,
pagine: 46 - 52
SICI:
0269-8811(200003)14:1<46:AAOAIT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MILD STRESS; SUBSTITUTED BENZAMIDE DRUGS; INDUCED ANHEDONIA; DOUBLE-BLIND; PLACE PREFERENCE; SCHIZOPHRENIC-PATIENTS; SUCROSE CONSUMPTION; RECEPTOR ANTAGONIST; MESOLIMBIC DOPAMINE; LIMBIC SELECTIVITY;
Keywords:
amisulpride; antidepressant action; chronic mild stress; dopamine receptors; forced swim test; imipramine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Papp, M Polish Acad Sci, Inst Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 rakow, Poland
Citazione:
M. Papp e J. Wieronska, "Antidepressant-like activity of amisulpride in two animal models of depression", J PSYCHOPH, 14(1), 2000, pp. 46-52

Abstract

Clinical reports suggest that amisulpride, in addition to its antipsychotic efficacy, may also have antidepressant properties. The present study was designed to evaluate potential antidepressant-like activity of amisulpride in two behavioural procedures: the forced swim test (FST) and the chronic mild stress (CMS) model. The duration of immobility time in FST was reduced by subchronic (three injections over a 24 h period) administration of imipramine (10 mg/kg) and amisulpride (1 and 3 mg/kg), although the effect of imipramine was more potent. The 5 mg/kg dose of amisulpride was marginally effective and higher doses of 10 and 30 mg/kg were inactive. In CMS, the stress-induced decrease in the consumption of 1% sucrose solution was graduallyreversed by chronic treatment with imipramine (10 mg/kg) and amisulpride (5 and 10 mg/kg). Lower (1 or 3 mg/kg) or higher (30 mg/kg) doses of amisulpride were inactive. The magnitude of the effect of active doses of amisulpride in the CMS model was comparable to that of imipramine but its onset of action was faster; at the most active dose of 10 mg/kg, amisulpride significantly increased the sucrose intake in stressed animals within 2 weeks of treatment while imipramine required 4 weeks before first effects on the stress-induced deficit in sucrose consumption could be observed. These results provide further support for clinical observations that amisulpride may posses potent and rapid antidepressant activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:55:10