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Titolo:
The effects of some antidepressant drugs on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response inman
Autore:
Phillips, MA; Langley, RW; Bradshaw, CM; Szabadi, E;
Indirizzi:
Univ Nottingham, Queens Med Ctr, Div Psychiat, Psychopharmacol Sect, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 14, anno: 2000,
pagine: 40 - 45
SICI:
0269-8811(200003)14:1<40:TEOSAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOMOTOR PERFORMANCE; HEALTHY-SUBJECTS; SCHIZOPHRENIA; REFLEX; HALOPERIDOL; APOMORPHINE; P50; AMITRIPTYLINE; AMPHETAMINE; DISRUPTION;
Keywords:
acoustic startle response; amitriptyline; antidepressants; auditory evoked potential; fluvoxamine; prepulse inhibition; reboxetine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bradshaw, CM Univ Nottingham, Queens Med Ctr, Div Psychiat, Psychopharmacol Sect, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH NG7 2UH, England
Citazione:
M.A. Phillips et al., "The effects of some antidepressant drugs on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response inman", J PSYCHOPH, 14(1), 2000, pp. 40-45

Abstract

Both the acoustic startle (eyeblink) response and the N1/P2 complex of theauditory evoked potential can be suppressed by presentation of a brief low-intensity stimulus 30-500 ms before the 'startle-eliciting' stimulus ('prepulse inhibition', PPI). We examined the effects of three antidepressants on PPI of these two responses. Fifteen males (19-30 years) participated in four weekly sessions, in which they received placebo, amitriptyline (100 mg), fluvoxamine (100 mg), and reboxetine (4 mg) (p.o.), according to a balanced double-blind design. Twenty minute simultaneous recordings of electromyographic (EMG) responses of the orbicularis oculi muscle of the right eye and vertex auditory evoked potentials were carried out 195 min after drug ingestion. Sound stimuli (1 kHz) were presented in 40 trials separated by variable intervals (mean 25 s): (1) 40 ms, 115 dB ('pulse alone', 20 trials) and (2) 40 ms, 85 dB, followed after 120 ms by 40 ms, 115 dB ('prepulse/pulse', 20 trials). Under the placebo condition, both the EMG response and the N1/P2 complex showed >50% PPI. Fluvoxamine and reboxetine did not significantly alter the amplitude or PPI of either response. Amitriptyline significantly reduced the amplitudes of both responses; it had no effect on PPI of the EMG response, but significantly attenuated PPI of the N1/P2 complex. Amitriptyline also reduced arousal, as indicated by an increase in power of low-frequency electroencephalographic waves. The results confirm the susceptibility of the N1/P2 complex to PPI. The reduction of the amplitudes of the EMG response and N1/P2 complex by amitriptyline may be related to its sedative action. The differential effect of amitriptyline on PPI of the N1/P2 complex supports the suggestion that different mechanisms may be involved in PPI of this response and PPI of the N1/P2 complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:21:18