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Titolo:
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
Autore:
Schmitt, JAJ; Jorissen, BL; Sobczak, S; van Boxtel, MPJ; Hogervorst, E; Deutz, NEP; Riedel, WJ;
Indirizzi:
Univ Limburg, Dept Psychiat & Neuropsychol Uns50, European Grad Sch Neurosci, NL-6200 MD Maastricht, Netherlands Univ Limburg Maastricht Netherlands NL-6200 MD D Maastricht, Netherlands Univ Limburg, Dept Surg, Brain & Behav Inst, European Grad Sch Neurosci, NL-6200 MD Maastricht, Netherlands Univ Limburg Maastricht Netherlands NL-6200 MD D Maastricht, Netherlands
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 14, anno: 2000,
pagine: 21 - 29
SICI:
0269-8811(200003)14:1<21:TDIMCB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE FUNCTIONS; ALZHEIMERS-DISEASE; PLASMA TRYPTOPHAN; SEROTONIN; BRAIN; MOOD; ANTIDEPRESSANTS; DEMENTIA; DEFICITS; MALES;
Keywords:
amino acids; attention; cognition; memory; serotonin; tryptophan depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitt, JAJ Univ Limburg, Dept Psychiat & Neuropsychol Uns50, European Grad Sch Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands Univ Limburg POB 616 Maastricht Netherlands NL-6200 MD lands
Citazione:
J.A.J. Schmitt et al., "Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers", J PSYCHOPH, 14(1), 2000, pp. 21-29

Abstract

Animal and human studies have provided evidence for serotonergic modulation of cognitive processes. However, the exact nature of this relationship isnot clear. We used the acute tryptophan depletion (ATD) method to investigate the effects of lowered serotonin synthesis on cognitive functions in 17healthy young volunteers. The study was conducted according to a placebo-controlled, double-blind, crossover design. Cognitive performance and mood were assessed at baseline and 5 and 9 h after administration of ATD. A specific impairment of word recognition, without effects on short-term memory, occurred during ATD. No memory deficits were seen if ATD was induced after acquisition of new words. The Stroop Test and dichotic listening task demonstrated a modality independent improvement of focussed attention after ATD. Fluency was also improved after ATD. ATD did not alter speed of informationprocessing, divided attention or planning functions. These results indicate that serotonin is essential in the process of long-term memory consolidation, primarily in the first 30 min after acquisition. Improvement of specific cognitive processes by lowered 5-HT function may be linked to the removal of inhibitory actions of 5-HT in the cortex.

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Documento generato il 25/01/20 alle ore 16:29:43