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Titolo:
Effects of hypothermia on intracranial pressure and brain edema formation:Studies in a rat acute subdural hematoma model
Autore:
Kawai, N; Nakamura, T; Okauchi, M; Nagao, S;
Indirizzi:
Kagawa Med Univ, Dept Neurol Surg, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 rg, Miki, Kagawa 7610793, Japan
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 3, volume: 17, anno: 2000,
pagine: 193 - 202
SICI:
0897-7151(200003)17:3<193:EOHOIP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; SEVERE HEAD-INJURY; GLUTAMATE ANTAGONIST; OXYGEN-CONSUMPTION; ARTERY OCCLUSION; MILD HYPOTHERMIA; DAMAGE; REDUCTION; METABOLISM; ISCHEMIA;
Keywords:
acute subdural hematoma; brain edema; hypothermia; intracranial pressure; NMDA antagonist; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kawai, N Kagawa Med Univ, Dept Neurol Surg, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Ikenobe Miki Kagawa Japan 7610793 3, Japan
Citazione:
N. Kawai et al., "Effects of hypothermia on intracranial pressure and brain edema formation:Studies in a rat acute subdural hematoma model", J NEUROTRAU, 17(3), 2000, pp. 193-202

Abstract

Acute subdural hematoma (SDH) is the most common mass lesion in severe head injury, and brain ischemia is the leading pathophysiological mechanism inthe development of secondary brain damage following SDH, Hypothermia has been employed as an effective neuroprotective procedure in clinical and laboratory studies on cerebral ischemic and contusional injuries, In the present study, we used a rat acute SDH model to assess the effect of hypothermia on the intracranial pressure (ICP) and also on the brain edema formation at4 h after hematoma induction. Mild (34 degrees C) and moderate (32 degreesC) hypothermia did not significantly affect the ICP or cerebral perfusion pressure, but they were associated with a significant lower cortical brain edema formation beneath the hematoma (81.09 +/- 0.49%, p < 0.05; and 80.88 /- 0.17%, p < 0.01) when compared with the normothermic control group (81.65 +/- 0.52%). This reduction in brain edema formation was comparable to the results of MK-801 treatment (80.95 +/- 0.35%, p < 0.01). The present findings indicate that hypothermia represents a potent neuroprotective strategy. The possible protective mechanisms of hypothermic protection afforded in this rat acute SDH model are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:44:40