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Titolo:
Anti-PMP22 antibodies in patients with inflammatory neuropathy
Autore:
Gabriel, CM; Gregson, NA; Hughes, RAC;
Indirizzi:
Guys Hosp, Guys Kings & St Thomas Sch Med, Dept Clin Neurosci, London SE1 9RT, England Guys Hosp London England SE1 9RT Clin Neurosci, London SE1 9RT, England
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 104, anno: 2000,
pagine: 139 - 146
SICI:
0165-5728(20000501)104:2<139:AAIPWI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC NEURITIS; GUILLAIN-BARRE-SYNDROME; EXPERIMENTAL AUTOIMMUNE NEURITIS; INTRAVENOUS IMMUNE GLOBULIN; MULTIFOCAL MOTOR NEUROPATHY; DEMYELINATING POLYRADICULONEUROPATHY; AXONAL DEGENERATION; GM1 GANGLIOSIDE; PLASMA-EXCHANGE; CLINICAL COURSE;
Keywords:
peripheral myelin protein 22 (PMP22); Guillain-Barre syndrome (GBS); chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); antibodies; inflammatory neuropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hughes, RAC Guys Hosp, Guys Kings & St Thomas Sch Med, Dept Clin Neurosci,Hodgkin Bldg, London SE1 9RT, England Guys Hosp Hodgkin Bldg London England SE1 9RT E1 9RT, England
Citazione:
C.M. Gabriel et al., "Anti-PMP22 antibodies in patients with inflammatory neuropathy", J NEUROIMM, 104(2), 2000, pp. 139-146

Abstract

An experimental model of inflammatory radiculoneuropathy is induced by immunising rats with peripheral myelin protein 22 (PMP22). We have investigated whether PMP22 may be important in inducing human inflammatory neuropathy. We examined sera of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), other neuropathies(ONP) and normal controls for IgM and IgG antibodies against PMP22 by ELISA (against synthetic PMP22 extracellular peptide fragments) and Western blot (against cauda equina). Antibodies were detected by both methods in 52% of patients with GBS, 35% with CIDP, 3% with ONP and no normal controls. We conclude that an immune response against PMP22 may play a role in the pathogenesis of the inflammatory neuropathies. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:50:33