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Titolo:
VACUUM-ASSISTED CLOSURE - A NEW METHOD FOR WOUND CONTROL AND TREATMENT - ANIMAL STUDIES AND BASIC FOUNDATION
Autore:
MORYKWAS MJ; ARGENTA LC; SHELTONBROWN EI; MCGUIRT W;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PLAST & RECONSTRUCT SURG,MED CTR BLVD WINSTON SALEM NC 27157
Titolo Testata:
Annals of plastic surgery
fascicolo: 6, volume: 38, anno: 1997,
pagine: 553 - 562
SICI:
0148-7043(1997)38:6<553:VC-ANM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-FLAP SURVIVAL; CHRONIC PRESSURE ULCERS; GROWTH FACTOR-BB; MECHANICAL STRETCH; CARDIAC MYOCYTES; PIG; CELLS; ANGIOGENESIS; HYPERTROPHY; ELONGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Morykwas et al., "VACUUM-ASSISTED CLOSURE - A NEW METHOD FOR WOUND CONTROL AND TREATMENT - ANIMAL STUDIES AND BASIC FOUNDATION", Annals of plastic surgery, 38(6), 1997, pp. 553-562

Abstract

A series of basic animal studies using a new subatmospheric pressure technique (The V.A.C.) to expedite wound healing are presented. The technique entails placing an open-cell foam into the wound, sealing the site with an adhesive drape, and applying subatmospheric pressure (125mmHg below ambient) that is transmitted to the wound in a controlled manner. Utilizing a pig model, four studies were undertaken to determine the effect of subatmospheric pressure on laser Doppler-measured blood flow in the wound and adjacent tissue (N = 5), rate of granulation tissue formation (N = 10), clearance of bacteria from infected wounds (N = 5), and measurement of nutrient flow by random-pattern flap survival (N = 5). Blood flow levels increased fourfold when 125 mmHg subatmospheric pressure was applied. Significantly increased rates of granulation tissue formation (p less than or equal to 0.05) occurred with both continuous (63.3% +/- 26.1%) and intermittent (103% +/- 35.3%) application. Tissue bacterial counts significantly decreased (p less than or equal to 0.05) after 4 days of application. Random-pattern flap survival significantly increased (p less than or equal to 0.05) by 21% compared to controls. We determined that the application of controlled subatmospheric pressure creates an environment that promotes wound healing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:52:14