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Titolo:
Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells
Autore:
Pierre, P; Shachar, I; Matza, D; Gatti, E; Flavell, RA; Mellman, I;
Indirizzi:
Yale Univ, Sch Med, Ludwig Inst Canc Res, Dept Cell Biol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Dept Cell Biol, New Haven, CT 06520 USA Yale Univ, Sch Med, Ludwig Inst Canc Res, Immunobiol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Immunobiol Sect, New Haven, CT 06520 USA Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Hughes Med Inst, New Haven, CT 06520 USA Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 6, volume: 191, anno: 2000,
pagine: 1057 - 1062
SICI:
0022-1007(20000320)191:6<1057:ICCHPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II MOLECULES; IN-VIVO; HLA-DM; INTRACELLULAR-TRANSPORT; MICE; RECONSTITUTION; COMPARTMENT; EXPRESSION;
Keywords:
invariant chain; H2-M; DM; cathepsin; dendritic cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Mellman, I Yale Univ, Sch Med, Ludwig Inst Canc Res, Dept Cell Biol, POB 208002,333 Cedar St, New Haven, CT 06520 USA Yale Univ POB 208002,333 Cedar St New Haven CT USA 06520 20 USA
Citazione:
P. Pierre et al., "Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells", J EXP MED, 191(6), 2000, pp. 1057-1062

Abstract

The association of invariant (Ii) chain with major histocompatibility complex (MHC) class II dimers is required for proper antigen presentation to T cells by antigen-presenting cells. Mice lacking Ii chain have severe abnormalities in class II transport, T cell selection, and B cell maturation. We demonstrate here that H2-M, which is required for efficient class II antigenic peptide loading, is unexpectedly downregulated in splenocytes and mature dendritic cells (DCs) from Ii(-/-) mice. Downregulation reflects an increased rate of degradation in Ii(-/-) cells. Degradation apparently occurs within lysosomes, as it is prevented by cysteine protease inhibitors such as E64, but not by the proteasome inhibitor lactacystin. Thus, Ii chain may act as a lysosomal protease inhibitor in B cells and DCs, with its deletion contributing indirectly to the loss of H2-M.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:51:54