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Titolo:
Nucleocytoplasmic shuttling of the Cdc42p exchange factor Cdc24p
Autore:
Nern, A; Arkowitz, RA;
Indirizzi:
MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH Div Cell Biol, Cambridge CB2 2QH, England
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 6, volume: 148, anno: 2000,
pagine: 1115 - 1122
SICI:
0021-9525(20000320)148:6<1115:NSOTCE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST; FAR1P;
Keywords:
nucleocytoplasmic shuttling; GDP/GTP exchange factor; Far1p; Cdc24p; polarized growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Arkowitz, RA MRC, Mol Biol Lab, Div Cell Biol, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH idge CB2 2QH, England
Citazione:
A. Nern e R.A. Arkowitz, "Nucleocytoplasmic shuttling of the Cdc42p exchange factor Cdc24p", J CELL BIOL, 148(6), 2000, pp. 1115-1122

Abstract

Cdc24p, the GDP/GTP exchange factor for the regulator of actin cytoskeleton Cdc42p, localizes to sites of polarized growth. Here we show that Cdc24p shuttles in and out of the yeast nucleus during vegetative growth. Far1p isnecessary and sufficient for nuclear accumulation of Cdc24p. suggesting that its nuclear import occurs via an association with Far1p. Nuclear export is triggered either by entry into the cell cycle or by mating pheromone. AsFar1p is degraded upon entry into the cell cycle, cell cycle-dependent export of Cdc24p occurs in the absence of Far1p, whereas during mating similarexport kinetics indicate that a Cdc24p-Far1p complex is exported. Our results suggest that the nucleus serves as a store of preformed Cdc24p-Far1p complex which is required for chemotropism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:53:39