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Titolo:
The effects of E-2 supplementation from the early proliferative phase to the late secretory phase of the endometrium in hMG-stimulated IVF-ET
Autore:
Jung, H; Roh, HK;
Indirizzi:
Chosun Univ, Coll Med, Dept Obstet & Gynecol, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 ecol, Kwangju 501759, South Korea
Titolo Testata:
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
fascicolo: 1, volume: 17, anno: 2000,
pagine: 28 - 33
SICI:
1058-0468(200001)17:1<28:TEOESF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO FERTILIZATION CYCLES; LUTEAL-PHASE; NONCONCEPTION CYCLES; OVARIAN STIMULATION; NATURAL CYCLES; IMPLANTATION; PROGESTERONE; RECEPTIVITY; CONCEPTION; APPEARANCE;
Keywords:
in vitro fertilization-embryo transfer; estradiol valerate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, H Chosun Univ, Coll Med, Dept Obstet & Gynecol, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 angju 501759, South Korea
Citazione:
H. Jung e H.K. Roh, "The effects of E-2 supplementation from the early proliferative phase to the late secretory phase of the endometrium in hMG-stimulated IVF-ET", J AS REPROD, 17(1), 2000, pp. 28-33

Abstract

Purpose: Our purpose was to determine if pregnancy rates (PRs) for hMG (human menopausal gonadotropin)-stimulated IVF-ET tin vitro fertilization-embryo transfer can be increased by estradiol (E-2) supplementation from the early proliferative phase to the late secretory phase of the endometrium. Method: Eighty-one infertile women with pure tubal factor were randomized into two groups. One group received no E-2 Supplementation (control group) and the other received oral E-2 supplementation (2 mg two times daily) fromthe early proliferative phase starting on the third day of the menstrual cycle to the late secretory phase of the endometrium, with hMG stimulation for ovulation induction starting on the sixth day of the menstrual cycle. Results: In 85 cycles, at least one embryo was transferred. Compared with the control group (n = 27 cycles), the E-2 supplementation group (n = 58 cycles) had a significantly higher PR (control, 25.9%, versus E-2 supplementation, 48.3%) and IR per ET(control, 10%, versus E-2 supplementation, 26%), but FRs per retrieved oocytes were not statistically different between the two groups(control, 74%, versus E-2 supplementation group, 73%). Four spontaneous abortions occurred in the E-2 supplementation group, and one case inthe control group. Ectopic pregnancy occurred in one case in the control group. Conclusions: Clinical PRs and IRs in the E-2 supplementation group were significantly higher than in the control group, while FRs in the control group did not differ statistically from the E-2 supplementation group. This suggests that E-2 supplementation from the early proliferative phase to the late secretory phase of the the endometrium in hMG-stimulated IVF-ET increases the receptivity of the endometrium for transferred embryos and clinical PRs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:50:24