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Titolo:
Physical, chemical, and biological evaluations of P760: A new gadolinium complex characterized by a low bate of interstitial diffusion
Autore:
Corot, C; Port, M; Raynal, I; Dencausse, A; Schaefer, M; Rousseaux, O; Simonot, C; Devoldere, L; Lin, J; Foulon, M; Bourrinet, P; Bonnemain, B; Meyer, D;
Indirizzi:
Guerbet, Biol Res, Div Res, F-95943 Roissy CDG, France Guerbet Roissy CDG France F-95943 s, Div Res, F-95943 Roissy CDG, France
Titolo Testata:
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 2, volume: 11, anno: 2000,
pagine: 182 - 191
SICI:
1053-1807(200002)11:2<182:PCABEO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST AGENTS; RESONANCE; ANGIOGRAPHY; EXCHANGE; ALBUMIN; INULIN;
Keywords:
MRI contrast agents; blood pool agents; pharmacokinetics; chemistry; relaxivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Corot, C Guerbet, Biol Res, Div Res, BP 50400, F-95943 Roissy CDG, France Guerbet BP 50400 Roissy CDG France F-95943 43 Roissy CDG, France
Citazione:
C. Corot et al., "Physical, chemical, and biological evaluations of P760: A new gadolinium complex characterized by a low bate of interstitial diffusion", J MAGN R I, 11(2), 2000, pp. 182-191

Abstract

An original gadolinium chelate, termed P760, which diffuses through the vascular endotheliun but at a much lower rate than nonspecific agents (NSA), is described. P760 is a gadolinium macrocyclic compound based on a DOTA structure that is substituted by hydrophilic bulky groups branched on the amino-carboxylic residues. The molecular weight is 5293, and the molecular volume, measured by light scattering, is 30 times higher (11.5 nm(3)) than thatof gadolinium (Gd)-DOTA (0.38 nm(3)). The increase in molecular volume andweight has two consequences: a) higher relaxivity (r1; 24.7 mM(-1).s(-1) compared with 3.4 mM(-1).s(-1) for Gd-DOTA at 20 Mhz, 37 degrees C); and b) a lengthening of its transport rate through the endothelium. P760 presents a peculiar pharmacokinetic profile: at early times post injection, the blood concentrations are higher than those of Gd-DOTA, but after 20 minutes, the blood concentrations are equal for the two compounds. The body clearancesof the products are identical (ie, glomerular filtration rate). P760 molecules are large enough to have a restricted diffusion through the endothelium but, conversely, small enough to pass freely through the glomerular membrane. This limited extravasation has been observed in rabbits by magnetic resonance angiography or in investigations of tumor permeability. Further experimental imaging studies are needed to define the clinical interest of such properties. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:04:51