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Titolo:
Opioids suppress chemokine-mediated migration of monkey neutrophils and monocytes - an instant response
Autore:
Miyagi, T; Chuang, LF; Lam, KM; Kung, HF; Wang, JM; Osburn, BI; Chuang, RY;
Indirizzi:
Univ Calif Davis, Sch Med, Dept Med Pharmacol & Toxicol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 rmacol & Toxicol, Davis, CA 95616 USA Univ Calif Davis, Dept Populat Hlth & Reprod, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 at Hlth & Reprod, Davis, CA 95616 USA NCI, Frederick Canc Res & Dev Ctr, Frederick, MD USA NCI Frederick MD USA CI, Frederick Canc Res & Dev Ctr, Frederick, MD USA Univ Calif Davis, Dept Vet Pathol Microbiol & Immunol, Davis, CA 95616 USAUniv Calif Davis Davis CA USA 95616 robiol & Immunol, Davis, CA 95616 USA
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 53 - 62
SICI:
0162-3109(200004)47:1<53:OSCMOM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMIAN-IMMUNODEFICIENCY-VIRUS; RECEPTOR GENE-EXPRESSION; MU-OPIATE RECEPTOR; MORPHINE-SULFATE; T-CELL; LYMPHOCYTES; INFECTION; COFACTOR; PROTEIN; 7-TRANSMEMBRANE;
Keywords:
opioids; interleukin-8 (IL-8); RANTES; chemotaxis; monkey leukocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chuang, RY Univ Calif Davis, Sch Med, Dept Med Pharmacol & Toxicol, Davis,CA 95616 USA Univ Calif Davis Davis CA USA 95616 xicol, Davis, CA 95616 USA
Citazione:
T. Miyagi et al., "Opioids suppress chemokine-mediated migration of monkey neutrophils and monocytes - an instant response", IMMUNOPHARM, 47(1), 2000, pp. 53-62

Abstract

Opioid users having acquired human immunodeficiency syndrome (AIDS) are ata greater risk than non-users of contracting opportunistic infections. Opioid-administered and simian immunodeficiency virus (SIV)-infected rhesus monkeys have been an excellent model for studying AIDS and drug abuse in humans. In this study, chemotaxis of monkey leukocytes was evaluated using the chemokines interleukin-8 (IL-8) and regulated upon activation, normal T cell expressed (RANTES) as the chemoattractants, and the effects of various opioid agonists and antagonists on the efficiency of chemotaxis were examined. Opioids were either incubated with monkey leukocytes or added directly tochemokines, and the number of cells migrating toward IL-8 (for neutrophils) or RANTES (for monocytes) was scored. Inhibition of chemotaxis was seen with both assay conditions, and the inhibition was mediated by opioids binding to mu or kappa receptors. Binding to delta opiod receptors was rarely, if ever, observed. Although opioids themselves may act as weak chemoattractants for monkey leukocytes, addition of opioid agonists to chemokines would reduce the chemoattractant ability of the chemokines. Opioids did not causethe same inhibitory effect on the chemotactic migration of neutrophils when the complement component C5a or the chemotactic peptide N-formyl-MET-LEU-PHE (fMLP) was used as chemoattractant. These studies suggest that the presence of opioids during SIV infection immediately alters cheomkine-mediated immune functions. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:00:48