Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitric oxide in the renal medulla protects from vasopressin-induced hypertension
Autore:
Szentivanyi, M; Park, F; Maeda, CY; Cowley, AW;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Semmelweis Univ Med, Dept Clin Res, Inst Physiol 2, Budapest, Hungary Semmelweis Univ Med Budapest Hungary Inst Physiol 2, Budapest, Hungary
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 35, anno: 2000,
pagine: 740 - 745
SICI:
0194-911X(200003)35:3<740:NOITRM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-PRESSURE REGULATION; BLOOD-PRESSURE; ARGININE; SYNTHASE; RATS;
Keywords:
arterial pressure; kidney; vasopressins; nitric oxide; endothelium; nitric oxide synthase; arginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cowley, AW Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd,POb 26509, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd,POb 26509 Milwaukee WI USA 53226
Citazione:
M. Szentivanyi et al., "Nitric oxide in the renal medulla protects from vasopressin-induced hypertension", HYPERTENSIO, 35(3), 2000, pp. 740-745

Abstract

In the present study, we assessed whether activation of the nitric oxide (NO) system within the renal medulla could serve as a buffer against the chronic hypertensive effects of arginine vasopressin (AVP). NO concentration in the renal medulla of Sprague-Dawley rats was measured with in vivo microdialysis/oxyhemoglobin NO trapping. The results showed that medullary interstitial [NO] was increased after 2 hours of AVP infusion and remained elevated even after 10 days (by 62+/-8% and 42+/-13%, respectively). Western blotanalysis showed that 2 days of AVP infusion was insufficient to increase protein expression of any of the NO synthase (NOS) isoforms, but after 10 days of AVP infusion, endothelial NOS expression was significantly increased in the inner medulla with no significant changes in noninducible NOS and inducible NOS levels. When renal medullary NOS enzyme activity was blunted with a nonpressor dose of N-G-nitro-L-arginine methyl ester (75 mu g . kg(-1). h(-1)) that was chronically infused locally into the renal medulla, intravenous AVP infusion (which was shown earlier to be subpressor in chronic studies) produced a sustained elevation in arterial pressure (from 107+/-2 to 121+/-2 mm Hg). These data indicate that chronic elevations in plasma AVPenhance renal medullary endothelial NOS protein expression, which enables sustained elevations of NO concentrations in this region of the kidney to buffer the hypertensive effects of AVP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:34:28