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Titolo:
Structurally diverse forms of HLA-B27 molecules are displayed in vivo in acell type-dependent manner
Autore:
Rehm, A; Rohr, A; Seitz, C; Wonigeit, K; Ziegler, A; Uchanska-Ziegler, B;
Indirizzi:
Humboldt Univ, Inst Immungenet, Klinikum Charite, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 um Charite, D-14050 Berlin, Germany Med Hsch Hannover, Transplantat Lab, Abdominal & Transplantat Chirurg Klin, Hannover, Germany Med Hsch Hannover Hannover Germany ntat Chirurg Klin, Hannover, Germany
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 4, volume: 61, anno: 2000,
pagine: 408 - 418
SICI:
0198-8859(200004)61:4<408:SDFOHM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; DIFFERENTIAL AVIDITY MODEL; MHC CLASS-I; MONOCLONAL-ANTIBODY; POSITIVE SELECTION; T-CELLS; ANTIGEN PRESENTATION; NEGATIVE SELECTION; PEPTIDE BINDING; LYMPHOCYTES-T;
Keywords:
monoclonal antibodies; peptide-dependent antibodies; HLA class I antigens; T cell selection; antigen presentation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, A Humboldt Univ, Inst Immungenet, Klinikum Charite, Campus Virchow Klinikum,Spandauer Damm 130, D-14050 Berlin, Germany Humboldt Univ CampusVirchow Klinikum,Spandauer Damm 130 Berlin Germany D-14050
Citazione:
A. Rehm et al., "Structurally diverse forms of HLA-B27 molecules are displayed in vivo in acell type-dependent manner", HUMAN IMMUN, 61(4), 2000, pp. 408-418

Abstract

The formation of a trimeric complex, composed of heavy chain (HC), beta(2)-microglobulin (beta(2)m) and antigenic peptide, is generally believed to be a prerequisite for the expression of HLA class I molecules at the cell surface in vivo. Therefore, a possible role in immunological processes for HC/beta(2)m complexes devoid of peptide has not been seriously considered. Using a novel HLA-B*2705-transgenic rat model and monoclonal antibodies that distinguish between structurally different forms of HLA-B27 molecules. we demonstrate here that class I molecules which appear to lack antigenic peptides are expressed in abundance on a variety of cell types in lymphoid organs. These results imply a role Tur structurally diverse, possibly empty, MHCmolecules in physiological T cell selection which has so far nor been sufficiently appreciated. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:47:43