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Titolo:
Multiple potential Intragenic regulatory elements in the CFTR gene
Autore:
Smith, DJ; Nuthall, HN; Majetti, ME; Harris, A;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS Inst Mol Med, Oxford OX3 9DS, England
Titolo Testata:
GENOMICS
fascicolo: 1, volume: 64, anno: 2000,
pagine: 90 - 96
SICI:
0888-7543(20000215)64:1<90:MPIREI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC-FIBROSIS GENE; PROMOTER REGION; MESSENGER-RNA; CELL LINE; EXPRESSION; IDENTIFICATION; LOCALIZATION; MUTATIONS; CHROMATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, A Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS ed, Oxford OX3 9DS, England
Citazione:
D.J. Smith et al., "Multiple potential Intragenic regulatory elements in the CFTR gene", GENOMICS, 64(1), 2000, pp. 90-96

Abstract

The CFTR gene exhibits a complex pattern of expression that shows temporaland spatial regulation though the control mechanisms have not been fully elucidated, We have mapped DNase I hypersensitive sites (DHS) flanking the CFTR gene to identify potential regulatory elements. We previously characterized DHS at -79.5 and -20.9 kb with respect to the CFTR translational startsite, DHS 3' to the gene at 4574 + 5.4-7.4 and 4574 + 15.6 kb, and a regulatory element in the first intron of the gene at 185 + 10 kb. We generated a cosmid contig to provide probes to evaluate the whole of the CFTR gene for DHS and have now mapped novel sites in introns 2, 3, 10, 16, 17a, 18, 20,and 21. These DHS show different patterns of cell-specific expression. (C)2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:13:25