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Titolo:
DELINEATION OF THE BORDER ZONE OF ISCHEMIC RABBIT MYOCARDIUM BY A TECHNETIUM-LABELED NITROIMIDAZOLE
Autore:
DIROCCO RJ; BAUER AA; PIRRO JP; KUCZYNSKI BL; BELNAVIS L; CHAN YW; LINDER KE; NARRA RK; NOWOTNIK DP; NUNN AD;
Indirizzi:
CEPHALON INC,145 BRANDYWINE PKWY W CHESTER PA 19380 BRISTOL MYERS SQUIBB PHARMACEUT RES INST PRINCETON NJ 08543
Titolo Testata:
Nuclear medicine and biology
fascicolo: 3, volume: 24, anno: 1997,
pagine: 201 - 207
SICI:
0969-8051(1997)24:3<201:DOTBZO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON COMPUTED-TOMOGRAPHY; BLOOD-FLOW; EMISSION TOMOGRAPHY; N-13 AMMONIA; RAT HEARTS; HYPOXIA; IDENTIFICATION; MISONIDAZOLE; INFARCTION; METABOLISM;
Keywords:
NUCLEAR CARDIOLOGY; ARTERY; RELATIVE MYOCARDIAL BLOOD FLOW (RMBF); MYOCARDIAL ISCHEMIA; HYPOXIA; MISONIDAZOLE; GLYCOLYSIS; MYOCARDIAL VIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Dirocco et al., "DELINEATION OF THE BORDER ZONE OF ISCHEMIC RABBIT MYOCARDIUM BY A TECHNETIUM-LABELED NITROIMIDAZOLE", Nuclear medicine and biology, 24(3), 1997, pp. 201-207

Abstract

Delineation of viable ischemic myocardium is an important problem in nuclear cardiology. To determine the feasibility of using a technetium-labeled nitroimidazole as an indicator of ischemic myocardium at riskof infarction, me characterized the distribution of a 2-nitroimidazole-derivatized PnAO ligand and its Tc-99m complex, (TcO)-Tc-99m(PnAO)-1-CH2-(2NI) (BMS-181321) in the ischemic territory of the left anteriordescending (LAD) coronary artery of the rabbit. In preliminary experiments, the performance of C-14-deoxyglucose (C-14-2DG) and C-14 misonidazole was assessed relative to apparent regional relative myocardial blood flow (rMBF) indicated by Tc-99m-teboroxime using double-label autoradiography in the rabbit LAD occlusion model. After demonstrating that C-14-2DG and C-14-misonidazole are selectively retained in the lateral border of the ischemic territory, BMS-181321 was co-injected intravenously, with either C-14-2DG or C-14-misonidazole, 20 min after LADocclusion. In a separate experiment, (TcO)-Tc-99m(pnAO)-6-CH3, a complex with the same lipophilicity (log k' 0.26 vs. 0.31) as BMS-181321 but which lacks the 2NI moiety, was co-injected with C-14-2DG. After 30min, the rabbits were sacrificed and C-14/(TC)-T-99m autoradiograms were obtained from the same tissue sections. The autoradiograms revealed that BMS-181321 was retained with the same microregional distribution as both C-14-2DG and C-14-misonidazole in the border zone of the ischemic LAD territory. The selective retention of BMS-181321 depends on the presence of the nitroimidazole group, since (TcO)-Tc-99m(PnAO)-6-CH3 has a uniformly low myocardial distribution in contrast to the enhanced uptake of co-injected C-14-2DG. These data demonstrate that BMS-181321 is selectively retained in hypoxic myocardium and demarcates theischemic border zone in a manner similar to C-14-2DG and C-14-misonidazole. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 03:51:49