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Titolo:
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma
Autore:
Bockhorn, M; Frilling, A; Kalinin, V; Schroder, S; Broelsch, CE;
Indirizzi:
Univ Clin Essen, Dept Gen & Transplantat Surg, D-45122 Essen, Germany UnivClin Essen Essen Germany D-45122 antat Surg, D-45122 Essen, Germany Univ Clin Eppendorf, Dept Gen Surg, Hamburg, Germany Univ Clin Eppendorf Hamburg Germany rf, Dept Gen Surg, Hamburg, Germany Inst Immunol Pathol & Mol Biol, Hamburg, Germany Inst Immunol Pathol & MolBiol Hamburg Germany l Biol, Hamburg, Germany
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 1, volume: 108, anno: 2000,
pagine: 49 - 53
SICI:
0947-7349(2000)108:1<49:AOHAKO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE ENDOCRINE NEOPLASIA; RET PROTOONCOGENE; GENETIC MECHANISMS; TUMOR INITIATION; LOW-FREQUENCY; N-MYC; CARCINOGENESIS; PROGRESSION; ACTIVATION; CANCER;
Keywords:
ras oncogene; sporadic medullary thyroid carcinoma; multiple endocrine neoplasia 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Frilling, A Univ Clin Essen, Dept Gen & Transplantat Surg, Hufelandstr 55,D-45122 Essen, Germany Univ Clin Essen Hufelandstr 55 Essen Germany D-45122 Germany
Citazione:
M. Bockhorn et al., "Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma", EXP CL E D, 108(1), 2000, pp. 49-53

Abstract

Medullary thyroid carcinoma (MTC) occurs sporadically (sMTC) or as part ofthe inherited cancer syndrome, multiple endocrine neoplasia type 2 (MEN 2). While the occurence of the MEN 2 syndrome is associated with mutations inthe RET protooncogene, the reason for carcinogenesis in sMTC still remainsunclear. Ras is a frequently mutated oncogene in a broad spectrum of human tumors and has been found in about 50% of follicular, papillary or anaplastic thyroid carcinomas. The purpose of this study was to determine, whether mutations in the ras oncogene could play a possible role in the carcinogenesis of sMTC. In this study we analyzed 15 sMTC for mutations in the hotspots codon 12, 13 and 61 of the H- and K-ras oncogene. We used the direct sequencing technique. In none of the examined tumors we were able to detect a mutation in the codon 12, 13 and 61 of the H-ras and K-ras oncogene. Based upon these results, we conclude that H- and K-ras do not play an important role in the carcinogenesis of sMTC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:26:33