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Titolo:
Effects of GYKI 52466 and some 2,3-benzodiazepine derivatives on hippocampal in vitro basal neuronal excitability and 4-aminopyridine epileptic activity
Autore:
Marinelli, S; Gatta, F; Sagratella, S;
Indirizzi:
Ist Super Sanita, Farmacol Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 a, Farmacol Lab, I-00161 Rome, Italy Ist Super Sanita, Lab Chim Farmaco, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 ab Chim Farmaco, I-00161 Rome, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 391, anno: 2000,
pagine: 75 - 80
SICI:
0014-2999(20000310)391:1-2<75:EOG5AS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-NMDA ANTAGONISTS; IN-VITRO; RAT; SLICES; RESPONSES; ASPARTATE; CALCIUM; DISCHARGES; GYKI-52466; NBQX;
Keywords:
GYKI 52466; 2,3-benzodiazepine; anticonvulsant; epilepsy; hippocampus; brain slice; epileptiform bursting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sagratella, S Ist Super Sanita, Farmacol Lab, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161
Citazione:
S. Marinelli et al., "Effects of GYKI 52466 and some 2,3-benzodiazepine derivatives on hippocampal in vitro basal neuronal excitability and 4-aminopyridine epileptic activity", EUR J PHARM, 391(1-2), 2000, pp. 75-80

Abstract

In order to determine whether the anticonvulsant effect of 2,3-benzodiazepines is also displayed in a model of in vitro epilepsy, such as the ''epileptiform' hippocampal slice, we studied the effects of 2,3-benzodiazepine 1-(4-aminophenyl)-1-methyl-7,8-methylenedioxe- 5H 2,3-benzadiazepine hydrochloride (GYKI 52466) and some new 2,3-benzodiazepine derivatives on CA1 basalneuronal excitability and on CAI epileptiform burst activity produced by 4-aminopyridine in rat hippocampal slices. The results showed that GYKI 52466 affected basal neuronal excitability as evidenced by its influence on themagnitude of the CAI orthodromic-evoked field potentials. 2,3-Benzodiazepines showed their antiepileptic effect also in an in vitro model of experimental epilepsy. The effects of the new 2,3-benzodiazepine derivatives suggest that the methylenedioxidation in positions 7 and 8 of the 2,3-benzodiazepine ring is the main structural modification for the antiepileptic effect of 2,3-benzodiazepines to take place. (C) 2000 Published by Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 08:59:53