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Titolo:
Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion
Autore:
Li, C; Lee, MJ; Sheng, SQ; Meng, XF; Prabhu, S; Winnik, B; Huang, BM; Chung, JY; Yan, SQ; Ho, CT; Yang, CS;
Indirizzi:
Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Lab, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Chem, Piscataway, NJ 08854 USA Environm & Occupat Hlth Sci INst, Piscataway, NJ 08854 USA Environm & Occupat Hlth Sci INst Piscataway NJ USA 08854 ay, NJ 08854 USA Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA Rutgers State Univ New Brunswick NJ USA 08901 New Brunswick, NJ 08901 USA
Titolo Testata:
CHEMICAL RESEARCH IN TOXICOLOGY
fascicolo: 3, volume: 13, anno: 2000,
pagine: 177 - 184
SICI:
0893-228X(200003)13:3<177:SIOTMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PORTAL-VEIN; GREEN TEA; (-)-EPIGALLOCATECHIN GALLATE; ABSORPTION; CANCER; POLYPHENOLS; CHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, CS Rutgers State Univ, Coll Pharm, Canc Res Lab, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 164 Frelinghuysen Rd Piscataway NJ USA 08854 A
Citazione:
C. Li et al., "Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion", CHEM RES T, 13(3), 2000, pp. 177-184

Abstract

Tea is a popular beverage consumed worldwide. The metabolic fate of its major constituents, catechins, however, is not well-known. In this study, twocatechin metabolites were detected in the urine and plasma of human volunteers after ingestion of green tea. These metabolites were identified by LC/ESI-MS and NMR as (-)-5-(3',4',5'-trihydroxyphenyl)-gamma-valerolactone (M4) and (-)-5-(3',4'-dihydroxyphenyl)-gamma-valerolactone (M6). The renal excretion of M4 and M6 had a 3 h lag time and peaked 7.5-13.5 h after ingestion of a single dose of green tea, while (-)-epigallocatechin (EGC) and (-)-epicatechin peaked at 2 h. M4 and M6 were two major tea metabolites with urinary cumulative excretions as high as 8-25 times the levels of EGC and (-)-epicatechin in some of our subjects, and accounted for 6-39% of the amountsof ingested EGC and (-)-epicatechin. Both the metabolites appeared to be produced by intestinal microorganisms, with EGC and (-)-epicatechin as the precursors of M4 and M6, respectively. Repeated ingestion of green tea produced a slight accumulative effect of the metabolites. They were also detected in the plasma, exhibiting kinetics similar to those of the urinary metabolites, and in the feces. Study on these metabolites may help us further understand the cancer chemopreventive actions and other beneficial effects of tea.

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Documento generato il 26/01/20 alle ore 00:51:58