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Titolo:
Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization
Autore:
Kimber, I; Cumberbatch, M; Dearman, RJ; Bhushnan, M; Griffiths, CEM;
Indirizzi:
AstraZeneca, Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England AstraZeneca Macclesfield Cheshire England SK10 4TJ 4TJ, Cheshire, England Univ Manchester, Hope Hosp, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD lford M6 8HD, Lancs, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 3, volume: 142, anno: 2000,
pagine: 401 - 412
SICI:
0007-0963(200003)142:3<401:CACITI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; COLONY-STIMULATING FACTOR; NODE DENDRITIC CELLS; DRAINING LYMPH-NODES; ANTIGEN-PRESENTING CELLS; MHC CLASS-II; INTERCELLULAR-ADHESION MOLECULE-1; CD44 VARIANT ISOFORMS; NORMAL HUMAN SKIN; CONTACT HYPERSENSITIVITY;
Keywords:
chemokines; cytokines; dendritic cells; Langerhans cells; migration;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
159
Recensione:
Indirizzi per estratti:
Indirizzo: Kimber, I AstraZeneca, Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England AstraZeneca Alderley Pk Macclesfield Cheshire England SK10 4TJ d
Citazione:
I. Kimber et al., "Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization", BR J DERM, 142(3), 2000, pp. 401-412

Abstract

Langerhans cells (LC) are members of the wider family of dendritic cells, LC reside in the epidermis where they serve as sentinels of the immune system, their responsibilities being to sample the external environment for changes and challenges and to deliver information (antigen) to responsive T lymphocytes within skin draining lymph nodes. The ability of LC to migrate from the epidermis to regional lymph nodes is therefore of pivotal importanceto the induction of cutaneous immune responses. The journey that LC have to make from the skin has a number of requirements, Initially it is necessary that LC disassociate themselves from surrounding keratinocytes and are liberated from other influences that encourage their retention in the epidermis, Subsequently migrating LC must successfully traverse the basement membrane of the dermal-epidermal junction and make their way, via afferent lymphatics, to draining lymph nodes. Effective entry into lymph nodes is necessary as is correct positioning of cells within the paracortex. There is increasing evidence that both cytokines and chemokines, and their interaction with appropriate receptors expressed by LC, orchestrate the mobilization and movement of these cells. We here consider the parts played by these molecules, and how collectively they induce and direct LC migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:18:34