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Titolo:
Lipid peroxidation, free radical production and antioxidant status in breast cancer
Autore:
Ray, G; Batra, S; Shukla, NK; Deo, S; Raina, V; Ashok, S; Husain, SA;
Indirizzi:
Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India Jamia Millia Islamia New Delhi India 110025 sci, New Delhi 110025, India Kalawati Saran Childrens Hosp, Dept Biochem, New Delhi, India Kalawati Saran Childrens Hosp New Delhi India Biochem, New Delhi, India All India Inst Med Sci, Inst Rotary Canc Hosp, Dept Surg Oncol, New Delhi,India All India Inst Med Sci New Delhi India Dept Surg Oncol, New Delhi,India All India Inst Med Sci, Inst Rotary Canc Hosp, Dept Med Oncol, New Delhi, India All India Inst Med Sci New Delhi India Dept Med Oncol, New Delhi, India Lady Hardinge Med Coll & Associated Hosp, Dept Surg, New Delhi, India LadyHardinge Med Coll & Associated Hosp New Delhi India w Delhi, India
Titolo Testata:
BREAST CANCER RESEARCH AND TREATMENT
fascicolo: 2, volume: 59, anno: 2000,
pagine: 163 - 170
SICI:
0167-6806(200001)59:2<163:LPFRPA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER OVARY CELLS; HYDROGEN-PEROXIDE; DNA DAMAGE; SUPEROXIDE ANION; OXYGEN RADICALS; MAMMALIAN-CELLS; INVITRO; MECHANISMS; DISMUTASE; CATALASE;
Keywords:
breast cancer; catalase; glutathione peroxidase; malondialdehyde; reactive oxygen metabolites; superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Husain, SA Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India Jamia Millia Islamia New Delhi India 110025 lhi 110025, India
Citazione:
G. Ray et al., "Lipid peroxidation, free radical production and antioxidant status in breast cancer", BREAST CANC, 59(2), 2000, pp. 163-170

Abstract

Reactive oxygen metabolites (ROMs), including superoxide anion (O-2(.-)), hydrogen peroxide (H2O2) and hydroxyl radical ((OH)-O-.), play an importantrole in carcinogenesis. There are some primary antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) whichprotect against cellular and molecular damage caused by the ROMs. We conducted the present study to determine the rate of O-2(.-) and H2O2 production, and concentration of malondialdehyde (MDA), as an index of lipid peroxidation, along with the SOD, GPx and CAT activities in 54 breast cancer (BC) patients. Forty-two age- and sex-matched patients with minor surgical problems, who had no history of any neoplastic or breast disorders, were taken ascontrols. The rate of O-2(.-) production was significantly higher (p < 0.001) in BC patients than controls, irrespective of clinical stages and menopausal status. Similarly, H2O2 production was significantly higher in BC patients, especially in stage III and postmenopausal groups, as compared to the respective controls. MDA concentration was also observed significantly elevated in stage II (p < 0.001), stage III (p < 0.01), postmenopausal (p < 0.005), andpremenopausal (p < 0.02) group as compared to their corresponding controls. SOD and GPx activities were found significantly raised in all the groups (p < 0.001), except the GPx activity was found a smaller alteration in stage IV (p < 0.02). On the contrary, CAT activity was found significantly depressed in all the study groups. The maximum depression was observed in stageII (-61.8%). Lower CAT activity in our study may be the effect of higher production of ROMs, particularly O-2(.-) and (OH)-O-.. SOD and GPx, however,were less effected by these higher ROMs production. The results of our study have shown a higher ROMs production and decreased CAT activity, which support the oxidative stress hypothesis in carcinogenesis. The relatively higher SOD and GPx may be due to the response of increased ROMs production in the blood. However, the higher SOD and GPx activities may be inadequate to detoxify high levels of H2O2 into H2O leading to the formation of the most dangerous (OH)-O-. radical followed by MDA. Therefore, administration of CAT may be helpful in the management of BC patients. However, further elaborate clinical studies are required to evaluate the role of such antioxidant enzymes in BC management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:20:23