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Titolo:
Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappa B activation
Autore:
Hisada, Y; Sakurai, H; Sugaya, T;
Indirizzi:
Tanabe Seiyaku Co Ltd, Discovery Res Lab, Yodogawa Ku, Osaka 5328505, Japan Tanabe Seiyaku Co Ltd Osaka Japan 5328505 ogawa Ku, Osaka 5328505, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 269, anno: 2000,
pagine: 309 - 316
SICI:
0006-291X(20000316)269:2<309:CTCIBM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; EXPERIMENTAL GLOMERULONEPHRITIS; CHEMOTACTIC FACTORS; GROWTH-FACTOR; GENE; TRANSCRIPTION; INDUCTION; MCP-1; RATS; SUPPRESSION;
Keywords:
mesangial cell; macrophage; monocyte chemoattractant protein-1; cell adhesion; nuclear factor kappa B; glomerulonephritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hisada, Y Tanabe Seiyaku Co Ltd, Discovery Res Lab, Yodogawa Ku, 16-89 Kashima 3 Chome, Osaka 5328505, Japan Tanabe Seiyaku Co Ltd 16-89 Kashima 3 Chome Osaka Japan 5328505
Citazione:
Y. Hisada et al., "Cell to cell interaction between mesangial cells and macrophages induces the expression of monocyte chemoattractant protein-1 through nuclear factor-kappa B activation", BIOC BIOP R, 269(2), 2000, pp. 309-316

Abstract

The interaction between mesangial cells (MCs) and monocytes/macrophages (Mo/Mo) is an important pathogenic feature of glomerulonephritis. However, its mechanism is not fully elucidated. Studies to date have focused on the interactions through mediators. In the present study, to obtain insight into the mechanism of the interaction between MCs and Mo/Mo, we examined the significance of the cell to cell interaction of these cells in the context of monocyte chemoattractant protein-1 (MCP-1) expression using cell contact cultures or co-culture without contact. Our results revealed that the cellular adhesion of cultured macrophages to MCs induced the expression of MCP-1, which was mainly observed in the MCs. In addition, the induction of MCP-I was, at least in part, mediated by nuclear factor kappa-B activation which occurs preferentially in the MCs. Because MCP-1 is suggested to play an important role in glomerulonephritis, this novel cell to cell interaction between the MCs and Mo/Mo could be important in glomerulonephritis. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:39:01