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Titolo:
CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness
Autore:
Haczku, A; Takeda, K; Hamelmann, E; Loader, J; Joetham, A; Redai, I; Irvin, CG; Lee, JJ; Kikutani, H; Conrad, D; Gelfand, EW;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 c Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 t Med, Denver, CO 80206 USA Mayo Clin, Scottsdale, AZ USA Mayo Clin Scottsdale AZ USAMayo Clin, Scottsdale, AZ USA Osaka Univ, Inst Mol & Cellular Biol, Osaka, Japan Osaka Univ Osaka Japan aka Univ, Inst Mol & Cellular Biol, Osaka, Japan Virginia Commonwealth Univ, Richmond, VA USA Virginia Commonwealth Univ Richmond VA USA wealth Univ, Richmond, VA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 161, anno: 2000,
pagine: 952 - 960
SICI:
1073-449X(200003)161:3<952:CENREO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN-NORWAY RATS; CELL-DEFICIENT MICE; FC-EPSILON-RII; B-CELL; LOW-AFFINITY; T-CELLS; PASSIVE TRANSFER; IGE PRODUCTION; EXPRESSION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gelfand, EW Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, 1400 JacksonSt, Denver, CO 80206 USA Natl Jewish Med & Res Ctr 1400 JacksonSt Denver CO USA 80206 A
Citazione:
A. Haczku et al., "CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness", AM J R CRIT, 161(3), 2000, pp. 952-960

Abstract

The effects of an anti-CD23 monoclonal antibody (B3B4) in CD23-deficient and CD23-overexpressing mice were compared in a murine model of allergic sensitization. After sensitization and challenge with OA, mice developed increased serum levels of OA-specific IgE and IgG(1) with airway eosinophilia and AHR when compared with nonsensitized animals, Anti-CD23 treatment was studied under two protocols: 10-d OA aerosol exposure and intraperitoneal sensitization followed by aerosol challenge. In both protocols anti-CD23 significantly reduced IgE and IgG(1) levels, abolished eosinophilia, and normalized AHR in BALB/c and wild-type CD23(+/+) mice but not in CD23(-/-) mice, These changes were associated with increases in IFN-gamma and decreases in IL-4 production, suggesting that CD23 binding may affect not only IgE production but also the Th1/Th2 imbalance during the development of allergic AHR. Absence of CD23 in gene-deficient mice significantly enhanced OA-specific IgE and IgG(1) levels, airway eosinophilia, and AHR when compared with CD23(/+) wild-type littermates after sensitization and airway challenge. Sensitized and challenged CD23 transgenic mice also developed eosinophilic airwayinflammation and methacholine hyperresponsiveness, However, the extent of AHR, BAL, and tissue eosinophilia in these animals showed a significant negative correlation with levels of CD23 expression on splenic T and B cells, demonstrating a limiting role of CD23 in the development of allergic AHR.

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Documento generato il 15/07/20 alle ore 05:27:18